Evidence map›Paper›PMID 40643527›Full record

ArticleCells2025

Mathematical Modeling Unveils a New Role for Transient Mitochondrial Permeability Transition in ROS Damage Prevention.

Olga A Zagubnaya, Vitaly A Selivanov, Mark Pekker, Carel J H Jonkhout, Yaroslav R Nartsissov, Marta Cascante

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Olga A ZagubnayaDepartment of Mathematical Modeling and Statistical Analysis, Institute of Cytochemistry and Molecular Pharmacology, Moscow 115404, Russia.
Vitaly A SelivanovDepartment of Biochemistry and Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-7937-9249
Mark PekkerMathematical Sciences Department, University of Alabama Huntsville, Huntsville, AL 35899, USA.
Carel J H JonkhoutMathematical Institute, Leiden University, 2300 RA Leiden, The Netherlands.
Yaroslav R NartsissovDepartment of Mathematical Modeling and Statistical Analysis, Institute of Cytochemistry and Molecular Pharmacology, Moscow 115404, Russia.ORCID 0000-0001-9020-7686
Marta CascanteDepartment of Biochemistry and Molecular Biomedicine, Faculty of Biology, Universitat de Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-2062-4633

Funding

CIBERehd CB17/04/00023MCIN/AEI/ 10.13039/501100011033 PID2023-150539OB-I00the Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR) Generalitat de Catalunya 2021-SGR-01328
6 · The paper itself

Abstract

We have previously shown that the mitochondrial respiratory chain (RC) can switch between the following two states: (i) an "ATP-producing" state characterized by the low production of reactive oxygen species (ROS), the vigorous translocation of hydrogen ions (H

Indexed as

MitochondriaModels, BiologicalModels, TheoreticalReactive Oxygen SpeciesAdenosine TriphosphateAnimalsHumansOxidative StressPermeabilityAdenosine TriphosphateReactive Oxygen Specieskinetic modelmitochondrial permeability transitionmitochondrial respiratory chain

Identifiers

PMID40643527
PMCPMC12248652

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.