Evidence map›Paper›PMID 40643523›Full record

ArticleCells2025

Growth Hormone Secretagogue Receptor (GHSR) Is Elevated in Myocardial Tissues of DMD

Maedeh Naghibosadat, Andrew McClennan, Margarita Egiian, Reema Flynn-Rizk, Tyler Lalonde, Carlie Charron, Anish Chhabra, Leonard G Luyt, Savita Dhanvantari, Lisa M Hoffman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maedeh NaghibosadatDepartment of Pathology and Laboratory Medicine, University of Western Ontario, London, ON N6A 3K7, Canada.
Andrew McClennanImaging Program, Lawson Research Institute/SJHC, London, ON N6C 2R5, Canada.ORCID 0000-0003-0084-3553
Margarita EgiianImaging Program, Lawson Research Institute/SJHC, London, ON N6C 2R5, Canada.
Reema Flynn-RizkImaging Program, Lawson Research Institute/SJHC, London, ON N6C 2R5, Canada.
Tyler LalondeDepartment of Chemistry, University of Western Ontario, London, ON N6A 3K7, Canada.
Carlie CharronDepartment of Chemistry, University of Western Ontario, London, ON N6A 3K7, Canada.ORCID 0000-0002-9022-255X
Anish ChhabraImaging Program, Lawson Research Institute/SJHC, London, ON N6C 2R5, Canada.
Leonard G LuytDepartment of Chemistry, University of Western Ontario, London, ON N6A 3K7, Canada.ORCID 0000-0002-0941-4731
Savita DhanvantariDepartment of Pathology and Laboratory Medicine, University of Western Ontario, London, ON N6A 3K7, Canada.ORCID 0000-0001-6453-1386
Lisa M HoffmanImaging Program, Lawson Research Institute/SJHC, London, ON N6C 2R5, Canada.ORCID 0000-0003-4409-5120

Funding

CIHR xxx
6 · The paper itself

Abstract

Dilated cardiomyopathy affects greater than 1 in 2500 patients worldwide, including those with the neuromuscular disorder Duchenne muscular dystrophy (DMD). While inflammation within skeletal muscle is strongly associated with DMD pathology, the key biomarkers for inflammation and possible targets for therapy within cardiac tissue in DMD-associated dilated cardiomyopathy remain to be identified. One such potential target is the myocardial ghrelin-growth hormone secretagogue receptor (GHSR) system, which is associated with cardiomyocyte survival and inhibition of inflammation. We sought to determine alterations in myocardial GHSR together with markers of cardiac inflammation using

Indexed as

InflammationMuscular Dystrophy, DuchenneMyocardiumReceptors, GhrelinUtrophinAnimalsBiomarkersCardiomyopathy, DilatedDisease Models, AnimalGhrelinMaleMiceMice, Inbred C57BLMice, Inbred mdxMice, KnockoutBiomarkersGhrelinReceptors, GhrelinUtrophindilated cardiomyopathyDuchenne muscular dystrophyGHSRinflammation

Identifiers

PMID40643523
PMCPMC12249256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.