Evidence map›Paper›PMID 40643492›Full record

ReviewCells2025

Perioperative Management of Non-Small Cell Lung Cancer in the Era of Immunotherapy.

Ulas Kumbasar, Erkan Dikmen, Zeliha Gunnur Dikmen, Ates Tenekeci, Ilgen Mender, Sergei Gryaznov, Burak Bilgin, Saadettin Kilickap

Abstract readReview
In one paragraph

Review in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ulas KumbasarDepartment of Thoracic Surgery, Faculty of Medicine, Hacettepe University, Ankara 06100, Türkiye.
Erkan DikmenDepartment of Thoracic Surgery, Faculty of Medicine, Hacettepe University, Ankara 06100, Türkiye.
Zeliha Gunnur DikmenDepartment of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara 06100, Türkiye.ORCID 0000-0001-7154-090X
Ates TenekeciDepartment of Medical Biochemistry, Faculty of Medicine, Hacettepe University, Ankara 06100, Türkiye.ORCID 0009-0007-6224-945X
Ilgen MenderDepartment of Research and Development, MAIA Biotechnology, Inc., Chicago, IL 60606, USA.ORCID 0000-0003-4542-327X
Sergei GryaznovDepartment of Research and Development, MAIA Biotechnology, Inc., Chicago, IL 60606, USA.ORCID 0009-0004-4743-8592
Burak BilginMedical Oncology, Yildirim Beyazit University, Ankara 06800, Türkiye.
Saadettin KilickapMedical Oncology, Liv Hospitals, Istinye University, Ankara 06800, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. Nonetheless, deeper molecular understanding of NSCLC has resulted in novel therapeutic approaches, including targeted therapy and immunotherapy, which have improved patient prognosis and outcomes in recent years. Immune checkpoint inhibitors (ICIs), with or without chemotherapy, are now considered valuable components of treatment for NSCLC cases that do not have specific actionable genetic mutations. Patients with actionable genetic mutations are candidates for targeted therapies. The primary focus of this review is the rationale for using ICIs in the perioperative setting for patients with resectable NSCLC and in advanced disease settings. Furthermore, we compare the benefits of using ICIs with the challenges associated with their clinical implementation in resectable and advanced NSCLC. Finally, we emphasize the development of novel treatment strategies that potentially provide an optimal treatment choice for patients with advanced NSCLC.

Indexed as

Carcinoma, Non-Small-Cell LungImmunotherapyLung NeoplasmsPerioperative CareHumansImmune Checkpoint InhibitorsImmune Checkpoint Inhibitorsadjuvant therapyimmunotherapyneoadjuvant therapyNSCLCtargeted therapy

Identifiers

PMID40643492
PMCPMC12248553

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.