Evidence map›Paper›PMID 40643487›Full record

ArticleCells2025

Neurofilament Light Chain in Serum and CSF as a Potential Biomarker for Primary Angiitis of the Central Nervous System.

Christina Krüger, Hans Pinnschmidt, Maximilian Wilmes, Justina Dargvainiene, Frank Leypoldt, Alexander Seiler, Daniela Berg, Tim Magnus, Milani Deb-Chatterji

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christina KrügerDepartment of Neurology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.ORCID 0009-0001-6544-7917
Hans PinnschmidtInstitute of Medical Biometry and Epidemiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Maximilian WilmesDepartment of Neurology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Justina DargvainieneNeuroimmunology Section, Institute of Clinical Chemistry, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.
Frank LeypoldtNeuroimmunology Section, Institute of Clinical Chemistry, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.
Alexander SeilerDepartment of Neurology, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.
Daniela BergDepartment of Neurology, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.
Tim MagnusDepartment of Neurology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Milani Deb-ChatterjiDepartment of Neurology, University Medical Center Schleswig-Holstein, 24105 Kiel, Germany.

Funding

Fielmann Förderstiftung
6 · The paper itself

Abstract

backgroundPrimary angiitis of the central nervous system (PACNS) is a rare vasculitis affecting CNS blood vessels, posing diagnostic challenges due to the limited specificity of the established diagnostic tools. Neurofilament light chain (NfL) might be a promising biomarker in PACNS.

methodsNfL in serum and CSF was measured in 33 PACNS patients (25 active [aPACNS], 8 in remission [rPACNS]) enrolled between 2014 and 2022 and compared to controls (serum:

conclusionsNfL holds potential as a biomarker for PACNS, in particular in younger patients.

Indexed as

BiomarkersNeurofilament ProteinsVasculitis, Central Nervous SystemAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedYoung AdultBiomarkersneurofilament protein LNeurofilament Proteinsautoimmune diseasesbiomarkerNfLPACNSstrokevasculitis

Identifiers

PMID40643487
PMCPMC12249180

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.