Evidence map›Paper›PMID 40643451›Full record

ReviewMagyar onkologia2025

New Perspectives and State of the Art in Interventional Radiotherapy (Brachytherapy) for Head and Neck Tumors.

Maria Concetta La Milia, Enrico Rosa, Pierpaolo Dragonetti, Bruno Fionda, Elisa Placidi, Valentina Lancellotta, Martina De Angeli, Francesco Pastore, Mariangela Massaccesi, Francesco Miccichè and 6 more

Abstract readReview
In one paragraph

Review in Magyar onkologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Maria Concetta La MiliaUniversità Cattolica del Sacro Cuore, Rome, Italy.
Enrico RosaFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. enrico.rosa@guest.policlinicogemelli.it.
Pierpaolo DragonettiUniversità Cattolica del Sacro Cuore, Rome, Italy.
Bruno FiondaFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. enrico.rosa@guest.policlinicogemelli.it.
Elisa PlacidiFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. enrico.rosa@guest.policlinicogemelli.it.
Valentina LancellottaFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. enrico.rosa@guest.policlinicogemelli.it.
Martina De AngeliFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. enrico.rosa@guest.policlinicogemelli.it.
Francesco PastoreFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. enrico.rosa@guest.policlinicogemelli.it.
Mariangela MassaccesiFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. enrico.rosa@guest.policlinicogemelli.it.
Francesco MiccichèOspedale Isola Tiberina-Gemelli Isola, Rome, Italy.
Leonardo BannoniFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. enrico.rosa@guest.policlinicogemelli.it.
Jacopo GalliUniversità Cattolica del Sacro Cuore, Rome, Italy.
Marco De SpiritoUniversità Cattolica del Sacro Cuore, Rome, Italy.
Maria Antonietta GambacortaUniversità Cattolica del Sacro Cuore, Rome, Italy.
Francesco BussuAzienda Ospedaliero Universitaria Sassari, Sassari, Italy.
Luca TagliaferriUniversità Cattolica del Sacro Cuore, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis review aims to evaluate the role of interventional radiotherapy (IRT - brachytherapy) in the clinical management of head and neck (H&N) cancers, focusing on recent technological advancements and their impact on clinical outcomes.

methodsA comprehensive literature review of clinical applications of IRT in H&N cancers was conducted, emphasizing the role of advanced imaging intensity-modulated IRT and custom applicators. The role of artificial intelligence and several dose calculation algorithms in treatment planning was also analyzed.

resultsIRT demonstrated efficacy across primary treatment, postoperative settings, and reirradiation, offering precise dose delivery while sparing adjacent healthy tissues. Innovations such as image-guided techniques and personalized 3D-printed applicators improved dosimetric accuracy and reduced toxicity. Functional outcomes were particularly favorable in sensitive anatomical regions like the nasal vestibule and oral cavity.

conclusionsIRT remains a cornerstone of precision oncology for head and neck cancers, achieving high efficacy, reduced toxicity, and improved patient quality of life. These advancements highlight its crucial role in modern oncologic care.

Indexed as

BrachytherapyHead and Neck NeoplasmsArtificial IntelligenceHumansQuality of LifeRadiotherapy DosageRadiotherapy, Image-GuidedRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedTreatment Outcome

Identifiers

PMID40643451
PMCPMC12255509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.