Evidence map›Paper›PMID 40643428›Full record

ArticleJournal of the American Society for Mass Spectrometry2025

Photocleavable Mass-Tagged Oligonucleotide Probes for Multiplexed and Multiomic Tissue Imaging of Targeted Transcripts.

Jonathan M Bell, Gargey Yagnik, Leonardo G Dettori, Philip Carvalho, Zhi Wan, Kenneth J Rothschild, Mark J Lim

Abstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jonathan M BellAmberGen, Inc., 44 Manning Road, Billerica, Massachusetts 01821, United States.
Gargey YagnikAmberGen, Inc., 44 Manning Road, Billerica, Massachusetts 01821, United States.ORCID 0000-0002-3197-3089
Leonardo G DettoriAmberGen, Inc., 44 Manning Road, Billerica, Massachusetts 01821, United States.ORCID 0000-0001-7333-3584
Philip CarvalhoAmberGen, Inc., 44 Manning Road, Billerica, Massachusetts 01821, United States.
Zhi WanAmberGen, Inc., 44 Manning Road, Billerica, Massachusetts 01821, United States.
Kenneth J RothschildAmberGen, Inc., 44 Manning Road, Billerica, Massachusetts 01821, United States.
Mark J LimAmberGen, Inc., 44 Manning Road, Billerica, Massachusetts 01821, United States.ORCID 0000-0002-5784-7195

Funding

Photocleavable Mass-Tags for Spatial Multiomics of Alzheimer’s Brain TissueR44AG078097 · NIA · AMBERGEN, INC · PI LIM, MARK · 2022 to 2023
$2.4M
A Highly Multiplexed, Multiomic 3D Mouse Brain Map Using MALDI-IHCR44MH132196 · NIMH · AMBERGEN, INC · PI LIM, MARK · 2022 to 2023
$2.0M
NIA NIH HHS R44 AG078097NIMH NIH HHS R44 MH132196
6 · The paper itself

Abstract

Many fluorescence-based

Indexed as

Oligonucleotide ProbesSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationAlzheimer DiseaseAnimalsBrainClick ChemistryFluorescent DyesIn Situ Hybridization, FluorescenceMiceRNAFluorescent DyesOligonucleotide ProbesRNAfluorescence in situ hybridizationimmunohistochemistryin situ hybridizationmass spectrometric imagingmatrix-assisted laser desorption/ionization mass spectrometrymultiplex imagingphotocleavable mass-tagsRNAspatial biologyspatial multiomicsspatial transcriptomics

Identifiers

PMID40643428
PMCPMC12333371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.