Evidence map›Paper›PMID 40643218›Full record

ArticleEuropean journal of neurology2025

Predictive Value of Perivascular Space Network and Choroid Plexus for Levodopa Responsiveness in Parkinson's Disease.

Zekai Chen, Sibo Huang, Yuefei Liang, Die Cai, Xi Zhou, Wenjie He, Jun Xia

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zekai ChenDepartment of Radiology, The First Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Sibo HuangDepartment of Radiology, The First Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Yuefei LiangDepartment of Radiology, The First Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Die CaiDepartment of Radiology, The First Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Xi ZhouDepartment of Radiology, South China Hospital, Medical School, Shenzhen University, Shenzhen, China.
Wenjie HeDepartment of Radiology, The First Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
Jun XiaDepartment of Radiology, The First Affiliated Hospital of Shenzhen University, Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.ORCID 0000-0002-5689-0343

Funding

Key Clinical Research Program of Shenzhen Second People's Hospital 20243357010National Natural Science Foundation of China 82171913Shenzhen Science and Technology Program JCYJ 20220818101816036
6 · The paper itself

Abstract

background and purposeInter-individual variability in levodopa responsiveness complicates personalized treatment of Parkinson's disease (PD). Previous studies have suggested that magnetic resonance imaging (MRI)-based indices of the perivascular space (PVS) and choroid plexus (CP) volume may be related to levodopa responsiveness. This study integrated multiple MRI indices, including CP volume, free water (FW) fraction, PVS volume fraction (PVSVF), and diffusion tensor imaging along the PVS (DTI-ALPS), to investigate their associations with levodopa responsiveness.

methodsThis retrospective study included 100 participants with PD (median age, 63.5 years; 53% females) who underwent 3T MRI between March 2023 and December 2024 and were grouped into good (n = 54) and poor (n = 46) responders based on the results of an acute levodopa challenge test. CP volume, FW fraction, PVSVF, and DTI-ALPS index were calculated. The Mann-Whitney U test and binary logistic regression were used for analysis.

resultsParticipants in the poor responder group had a higher CP volume (p = 0.048) and FW fraction (p < 0.01) than those in the good responder group. Higher CP volume (odds ratio [OR], 0.986; p = 0.038) and FW fraction (odds ratio [OR], 0.883; p < 0.01) were significantly associated with poor levodopa responsiveness, while higher PVS volume fraction, higher PVSVF-BG, higher PVSVF-WM, and lower DTI-ALPS were not.

conclusionHigher CP volume and FW fraction were independently associated with poor levodopa responsiveness. CP volume and FW fraction measurements may be valuable imaging biomarkers for predicting levodopa responsiveness.

Indexed as

Antiparkinson AgentsChoroid PlexusGlymphatic SystemLevodopaParkinson DiseaseAgedDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPredictive Value of TestsRetrospective StudiesAntiparkinson AgentsLevodopachoroid plexusdiffusion tensor imagingmagnetic resonance imagingParkinson's diseaseperivascular spaces

Identifiers

PMID40643218
PMCPMC12247183

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.