Evidence map›Paper›PMID 40643205›Full record

ArticleACS applied materials & interfaces2025

Real-Time Monitoring of Adenosine Triphosphate Fluctuation in Lysosome during Autophagy/Mitophagy.

Jiwen Hu, Hong Wang, Xin Zhang, Chunfei Wang, Anna du Rietz, Mengtao Rong, Caroline Brommesson, Xiongyu Wu, Zhanxiao Wei, Ruilong Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jiwen HuDepartment of Physics, Chemistry, and Biology (IFM), Linköping University, Linköping SE-581 83, Sweden.ORCID 0009-0004-1407-5596
Hong WangSchool of Chemistry and Chemical Engineering, and Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China.
Xin ZhangDepartment of Physics, Chemistry, and Biology (IFM), Linköping University, Linköping SE-581 83, Sweden.ORCID 0000-0003-4393-2804
Chunfei WangCancer Centre and Centre of Reproduction, Development and Aging, Faculty of Health Science, University of Macau, Taipa, Macau SAR 999078, China.
Anna du RietzDepartment of Physics, Chemistry, and Biology (IFM), Linköping University, Linköping SE-581 83, Sweden.ORCID 0000-0001-9078-8425
Mengtao RongSchool of Chemistry and Chemical Engineering, and Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China.
Caroline BrommessonDepartment of Physics, Chemistry, and Biology (IFM), Linköping University, Linköping SE-581 83, Sweden.
Xiongyu WuDepartment of Physics, Chemistry, and Biology (IFM), Linköping University, Linköping SE-581 83, Sweden.ORCID 0000-0001-6756-2276
Zhanxiao WeiDepartment of Physics, Chemistry, and Biology (IFM), Linköping University, Linköping SE-581 83, Sweden.
Ruilong ZhangSchool of Chemistry and Chemical Engineering, and Institute of Physical Science and Information Technology, Anhui University, Hefei, Anhui 230601, China.ORCID 0000-0002-9585-3203
Xuanjun ZhangCancer Centre and Centre of Reproduction, Development and Aging, Faculty of Health Science, University of Macau, Taipa, Macau SAR 999078, China.ORCID 0000-0001-6452-1778
Kajsa UvdalDepartment of Physics, Chemistry, and Biology (IFM), Linköping University, Linköping SE-581 83, Sweden.ORCID 0000-0002-0314-4291
Zhangjun HuDepartment of Physics, Chemistry, and Biology (IFM), Linköping University, Linköping SE-581 83, Sweden.ORCID 0000-0001-9905-0881

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy, a lysosomal degradation pathway critical for cell survival, differentiation, development, and maintaining homeostasis, plays a crucial role in cellular health. Maintaining an adequate level of adenosine triphosphate (ATP), the central molecule in energy metabolism, is equally essential for these processes. However, the interplay between autophagy and energy metabolism remains incompletely understood due to technical challenges, including the need for high-precision, dynamic detection within organelles, and sensitivity to the acidic lysosomal environment. To address these limitations, we developed HR-MP, a ratiometric fluorogenic nanoprobe specifically designed for visualizing ATP levels in acidic lysosomes during autophagy. HR-MP exhibits selective, rapid, and quantitative ATP detection

Indexed as

Adenosine TriphosphateAutophagyFluorescent DyesLysosomesHeLa CellsHumansAdenosine TriphosphateFluorescent DyesATP monitoringFörster resonance energy transfer (FRET)lysosome targetingratiometric fluorogenic nanoprobesilica nanoparticles

Identifiers

PMID40643205
PMCPMC12291090

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.