Evidence map›Paper›PMID 40643076›Full record

SynthesisJournal of surgical oncology2025

Association Between Mesorectal Grade and Oncologic Outcomes in Rectal Cancer: A Systematic Review and Meta-Analysis.

Peter Rogers, Justin Dourado, Sameh Hany Emile, Anjelli Wignakumar, Zachary Delgado, Pauline Aeschbacher, Zoe Garoufalia, Victor Strassmann, Steven D Wexner

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Peter RogersEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.ORCID https://orcid.org/0000-0003-0963-7094
Justin DouradoEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.
Sameh Hany EmileEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.ORCID https://orcid.org/0000-0001-7854-5244
Anjelli WignakumarEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.
Zachary DelgadoRoss University School of Medicine, Miramar, Florida, USA.
Pauline AeschbacherDepartment of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Zoe GaroufaliaEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.
Victor StrassmannEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.ORCID https://orcid.org/0000-0001-6954-4733
Steven D WexnerEllen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.ORCID https://orcid.org/0000-0001-8046-5753

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

We aimed to clarify the impact of TME grading on recurrence and survival. PubMed and Scopus were searched. The main outcome measures were local and distant recurrence and overall survival. Ten studies (2002-2023) were analyzed. Patients with incomplete TME exhibited lower overall survival (HR 0.75, p = 0.044) and higher local (RR 3.09, p = 0.001) and distant (RR 1.44, p = 0.005) recurrence rates compared to complete/near-complete TME. Complete and near-complete TME had similar risk of local recurrence, distant metastasis, and overall survival. This meta-analysis supports the crucial role of TME in rectal cancer outcomes.

Indexed as

Neoplasm Recurrence, LocalRectal NeoplasmsHumansNeoplasm GradingSurvival Ratemesorectal grademeta‐analysisoncologic outcomesrectal cancersystematic review

Identifiers

PMID40643076
PMCPMC12455534

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.