ReviewChemistry (Weinheim an der Bergstrasse, Germany)2025
The Versatility of Diazirines: Properties, Synthetic and Modern Applications.
Review in Chemistry (Weinheim an der Bergstrasse, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Universal charge-tag labelling of undetectable polymers for mass spectrometric characterization.Chemical science · 2026Article
- Allosteric activation of Trx1 by antagonizing nitrative modification at tyrosine 49 confers neuroprotection against ischemic stroke.Redox biology · 2026Article
- Article
- Unactivated Photoredox C-H Amination with Diazirines: Access to Acyldiaziridines.Organic letters · 2026Article
- Diazirines Beyond Photoaffinity Labeling: A Comprehensive Overview of Applications in Biological Sciences, Materials Chemistry, and NMR-Spectroscopy.Angewandte Chemie (International ed. in English) · 2026Review
- Design, synthesis and SAR studies of N'-(Ethynylsalicylidene)arenecarbohydrazides as next-generation broad-spectrum antifungal agents.Bioorganic & medicinal chemistry · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diazirines are 3-membered heterocycles containing two nitrogen atoms connected by a double bond. They are mostly known for their usage in photoaffinity labeling (PAL), due to their stability and their facile photolysis for on-demand carbene generation. Yet diazirines possess a multi-faceted reactivity that also holds great potential for organic synthesis. This is illustrated in the present review, which is meant to be a beginner's guide for new diazirine users. After briefly summarizing the main synthetic approaches to these derivatives (with a focus on recent improvements), we emphasize some of their most critical features and properties before describing the various modes of activation toward carbene generation, some of which were only uncovered in the past decade. We then review the many modern uses of diazirines, underlining their underappreciated versatility: as carbene precursors in synthesis, but also as electrophilic nitrogen donors, as NMR hyperpolarization probes, or as molecular tools in materials science.
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Registered trials
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