Evidence map›Paper›PMID 40642980›Full record

ArticleMicrobiology spectrum2025

Machine learning-selected minimal features drive high-accuracy rule-based antibiotic susceptibility predictions for

Xuefeng Jia, Yongfen Xiong, Yanping Xu, Fangyuan Chen, Peng Han, Jieming Qu, Quanli He, Guanhua Rao

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xuefeng Jia *Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin, China.
Yongfen Xiong *Department of Medical Laboratory, Wuhan No.1 Hospital, Wuhan, China.
Yanping XuDepartment of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fangyuan ChenGenskey Medical Technology Co., Ltd, Beijing, China.
Peng HanGenskey Medical Technology Co., Ltd, Beijing, China.
Jieming QuDepartment of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Quanli HeDepartment of Clinical Laboratory, The People's Hospital of Jiaozuo, Jiaozuo, China.ORCID 0009-0000-7111-795X
Guanhua RaoGenskey Medical Technology Co., Ltd, Beijing, China.ORCID 0000-0003-4408-208X

Funding

Major Innovation Fund for Tianjin Cultivating Leading Technological Enterprises 24YDPYSY00130Noncommunicable Chronic Diseasses-National Science and Technology Major Project 2023ZD0506200
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) represents a critical global health challenge, demanding rapid and accurate antimicrobial susceptibility testing (AST) to guide timely treatments. Traditional culture-based AST methods are slow, while existing whole-genome sequencing (WGS)-based models often suffer from overfitting, poor interpretability, and diminished performance on clinical metagenomic data. In this study, we developed an interpretable genotypic AST approach for

Indexed as

Anti-Bacterial AgentsMachine LearningMetagenomicsStaphylococcus aureusDrug Resistance, BacterialGenome, BacterialGenotypeHumansMicrobial Sensitivity TestsStaphylococcal InfectionsWhole Genome SequencingAnti-Bacterial Agentsantibiotic susceptibility predictionsmachine learningmetagenomic sequencingrule-based modelStaphylococcus aureusvancomycin

Identifiers

PMID40642980
PMCPMC12323339

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.