ArticleInternational journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics2026
The association between levonorgestrel intrauterine devices and female fertility compared to other contraceptive methods: A historical cohort study.
Article in International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The association between levonorgestrel intrauterine devices and female fertility compared to other contraceptive methods: A historical cohort study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
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6 authors.
Funding
Abstract
objectiveThis study aimed to investigate whether the use of levonorgestrel intrauterine devices (LNG-IUD) is associated with an increased need for medically assisted reproductive (MAR) treatment compared to other contraceptive methods.
methodsThis register-based historical cohort study included 733 875 Danish women aged 18-42 years between 2000 and 2018. The primary outcome was initiation of MAR treatment in the public healthcare sector. The exposure was categorized as the use of either LNG-IUD, copper (Cu)-IUD, progesterone-only pills (POPs) or combined oral contraceptive pills (OCPs) during the study period. Cox proportional hazard regression was used to assess the risk of initiation of MAR treatment after LNG-IUD use relative to other contraceptive methods.
resultsAdjusted analysis revealed that POPs and OCPs were associated with increased hazards of MAR treatment relative to LNG-IUD with hazard ratios (HR) of 2.91 (95% confidence interval (CI): 1.81-4.68, P < 0.001) and 6.58 (95% CI: 4.32-10.02, P < 0.001), respectively, while no difference was observed for Cu-IUD relative to LNG-IUD (HR 1.17, 95% CI: 0.61-2.25, P = 0.644).
conclusionUse of LNG-IUD was not associated with an increased need to undergo MAR treatment compared to Cu-IUD, POPs and OCPs. However, due to limitations of the current study more research is needed in order to determine whether the use of LNG-IUD has a negative effect on female fertility.
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