SynthesisCancer medicine2025
Preoperative Hepatic Augmentation Versus Transarterial Chemoembolization for Hepatocellular Carcinoma With Insufficient Remnant Liver Volume: A Systematic Review and Meta-Analysis.
Synthesis in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreasing remnant liver volume before major liver resection is an effective measure to reduce postoperative adverse events of hepatocellular carcinoma (HCC). We aimed to provide evidence for optimal management of HCC patients with insufficient future remnant liver volume (FRLV).
methodsA comprehensive search of various large medical databases, research registry platforms, and gray literature was performed up to May 2023. All comparative studies grouped by preoperative hepatic augmentation (PHA) and transarterial chemoembolization (TACE) were included. A random-effects model was used for meta-analysis, and the heterogeneity of the results was quantitatively assessed by funnel plots, sensitivity analyses, and subgroup analyses.
resultsA total of eight comparative studies were selected for inclusion in this analysis, including 3523 patients. 5-year overall survival (hazard ratio [HR] = 1.52, 95% confidence intervals [CI] = 1.07-2.15) and disease-free survival (HR = 1.72, 95% CI = 1.40-2.10) were significantly different between the PHA and TACE groups. There was no significant difference between PHA and TACE with respect to 90-day mortality, postoperative complication rate, or serious complication rate (p > 0.05). In subgroup analysis, compared with portal vein embolization, associating liver partition and portal vein ligation was highly associated with longer survival and fewer recurrences (p < 0.05). None of the above results exhibited obvious bias or heterogeneity.
conclusionsThis study demonstrates that PHA allows for radical liver resection for HCC patients with insufficient FRLV without increasing the incidence of postoperative adverse events, which can effectively improve patient outcomes and delay tumor recurrence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.