Evidence map›Paper›PMID 40642838›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone-Glucocorticoid Receptor-LAMA5 Axis.

Chuanjing Zhang, Yongfei Song, Xiaojun Jin, Qingbo Xu, Honghua Ye, Zhuonan Wu, Hui Lin, Jiale Hu, Chen Huang, Jianqing Zhou and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chuanjing Zhang *The Affiliated Lihuili Hospital of Ningbo University, Health Science Center, Ningbo University, Ningbo, Zhejiang, 315000, China.ORCID https://orcid.org/0000-0002-8710-1845
Yongfei Song *The Affiliated Lihuili Hospital of Ningbo University, Health Science Center, Ningbo University, Ningbo, Zhejiang, 315000, China.ORCID https://orcid.org/0000-0001-6762-9899
Xiaojun JinThe Affiliated Lihuili Hospital of Ningbo University, Health Science Center, Ningbo University, Ningbo, Zhejiang, 315000, China.
Qingbo XuDepartment of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China.
Honghua YeThe Affiliated Lihuili Hospital of Ningbo University, Health Science Center, Ningbo University, Ningbo, Zhejiang, 315000, China.
Zhuonan WuDepartment of Cardiology, Shaoxing Second Hospital, Shaoxing, Zhejiang, 312000, China.
Hui LinThe Affiliated Lihuili Hospital of Ningbo University, Health Science Center, Ningbo University, Ningbo, Zhejiang, 315000, China.
Jiale HuThe Affiliated Lihuili Hospital of Ningbo University, Health Science Center, Ningbo University, Ningbo, Zhejiang, 315000, China.
Chen HuangDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University School of Health Science Center, Xi'an, Shaanxi, 710061, China.
Jianqing ZhouThe Affiliated Lihuili Hospital of Ningbo University, Health Science Center, Ningbo University, Ningbo, Zhejiang, 315000, China.
Jiangfang LianThe Affiliated Lihuili Hospital of Ningbo University, Health Science Center, Ningbo University, Ningbo, Zhejiang, 315000, China.ORCID https://orcid.org/0000-0002-3573-8051

Funding

Huadong Medicine Joint Funds of Zhejiang Provincial Natural Science Foundation of China LHDMZ24H020001National Natural Science Foundation of China 81870255National Natural Science Foundation of China 82300347Ningbo Key Research and Development Program 2024Z210Ningbo Municipal Key Laboratory for Molecular Target Screening and Applications 2023-BZDSZhejiang Provincial Science Foundation of China LY21H020001
6 · The paper itself

Abstract

Chronic psychological stress is closely related to myocardial diseases, but the pathological processes and related mechanisms are not yet clear. In this study, 5 batches of animal experiments are conducted to reveal the pathological process of chronic psychological stress on the heart, and found that cardiomyocyte hypertrophy is an early manifestation of cardiac damage. Furthermore, it is discovered that corticosterone and glucocorticoid receptor (GR) play an important role in mediating this phenomenon. Additionally, a new direct target gene of GR, Lama5, is identified and confirmed in vivo and in vitro that the corticosterone-GR-LAMA5 axis is a significant pathway mediating chronic psychological stress-induced cardiomyocyte hypertrophy. Moreover, the potential of LAMA5 is validated as a biomarker for myocardial hypertrophy and impaired cardiac function in patients with depression. In summary, a novel hypertrophy-related gene, Lama5 has been identified, that may play an important role in chronic psychological stress-induced cardiomyocyte hypertrophy.

Indexed as

CardiomegalyCorticosteroneLamininMyocytes, CardiacReceptors, GlucocorticoidStress, PsychologicalAnimalsHumansHypertrophyMaleRatsCorticosteroneLamininReceptors, Glucocorticoidcardiomyocyte hypertrophychronic psychological stresscorticosteroneglucocorticoid receptorslaminin subunit alpha 5

Identifiers

PMID40642838
PMCPMC12463095

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.