Trial reportJournal of cosmetic dermatology2025
Application of Antioxidant Mixture Prevents Cutaneous "Oxinflammaging" in Subjects Exposed to Particulate Matter.
Trial report in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- A New Cosmeceutical Approach for Mature Skin: Antioxidant Activity, In Vitro Permeation, and Preliminary Clinical Efficacy of Melatonin-N-Acetylcysteine Creams.Antioxidants (Basel, Switzerland) · 2026Article
- Clinical Applications of Vitamin C in Dermatology: A Systematic Review.The Journal of clinical and aesthetic dermatology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundPremature skin aging and the growing incidence of skin conditions are closely linked to daily exposure to environmental agents. Among all air pollutants, particulate matter (PM) is regarded as one of the most aggressive in terms of skin damage, promoting degradation of extracellular matrix (ECM) components and depletion of the cutaneous antioxidant defense via initiation of oxinflammatory reactions. Moreover, PM can penetrate damaged skin, exacerbating the effect of other pollutants and worsening the symptoms of existing skin conditions. Topical application of antioxidant compounds can limit and, in certain cases, even prevent skin damage.
objectiveIn the present study, a randomized clinical study was conducted to evaluate the protective effects of a topically applied antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol (AOX Mix) against the PM-induced skin damage.
methodsFor this purpose, the back of 15 female volunteers, between 19-40 years and with skin phototypes III and IV, was pre-treated with AOX Mix and exposed daily to PM for 4 days. Skin sample biopsies were subsequently collected and subjected to histological analysis to evaluate the key markers related to skin "oxinflammaging".
resultsThe AOX Mix demonstrated protective effects against the cutaneous degradation of ECM components, including type I and III collagens, elastin, and tropoelastin. It also mitigated markers of inflammation (COX2), oxidative stress (4-hydroxynonenal), and structural damage (involucrin, filaggrin, claudin-1, desmocollin 1).
conclusionRegular topical application of an antioxidant cosmeceutical formulation represents an effective strategy to counteract the detrimental effects of environmental insults, particularly with respect to inflammaging.
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Registered trials
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