ArticleJournal of biosciences2025
Postbiotic potential of SCFAs on metaflammation and gut microbiota alteration in diabetes.
Article in Journal of biosciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Gut microbiota and uric acid excretion signaling in pathogenesis of hyperuricemia and acute gouty arthritis.iScience · 2026Article
- Metainflammation, Mitochondrial Dysfunction, and Organokine Crosstalk: A Central Axis Linking Metabolic Syndrome to Cardiovascular Diseases.International journal of molecular sciences · 2026Review
- Inulin alleviates vascular cognitive impairment by restoring prefrontal GABAergic function via microbiota-SCFA-GPR41/43 axis.Microbiome · 2026Article
- The Interplay Between GLP-1-Based Therapies, the Gut Microbiome, and MASLD/MASH in Type 2 Diabetes Mellitus: A Narrative Review.Biomedicines · 2026Review
- Postbiotics of Marine Origin and Their Therapeutic Application.Marine drugs · 2025Review
- Microbial transformation: the role of fermentation in advancing nutritional quality and human health.Archives of microbiology · 2025Review
- Mechanisms of Dangguiliuhuang Tang in Streptozotocin-Induced Type 2 Diabetes Mellitus Mice Based on Network Pharmacology, Gut Microbiota, and Experimental Validation.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Adipose-derived stem cell extracellular vesicles attenuate liver fibrosis via restoration of gut barrier function and modulation of gut microbiota.Extracellular vesicles and circulating nucleic acids · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gut microbiota regulate host metabolism via its fermentation products, mainly short-chain fatty acids (SCFAs), i.e., acetate, propionate, and butyrate. Although butyrate is studied for its anti-inflammatory, anti-obesity, and anti-diabetic effects, propionate alone and in combination with acetate or butyrate is not well reported. In this study, we have shown the combinatorial effect of propionate with acetate or butyrate in the regulation of diabetes characteristics, liver metabolism, and inflammation via SCFA receptors and gut microbiota modulation. Diabetes was induced by high-fat diet administration for 4 months and was followed by oral administration of SCFAs for 1 month. Although propionate and butyrate alone showed reduced diabetic characteristics, a combination of propionate with acetate or butyrate more significantly regulated insulin downstream pathway molecules, i.e., liver X receptor (LXR), sterol regulatory element binding protein 1c (SREBP1c), glucose transporter type 4 (GLUT4), and peroxisome-proliferator-activated receptor alpha (PPARα), and enhanced the expression of SCFA receptors, i.e., G-protein-coupled receptor 41 (GPR41), GPR43, and GPR109 in the liver. They increased microbial richness and evenness along with the restoration of probiotic bacterial strains, healthy bacteria, as well as butyrate producers, mainly,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.