ArticleFrontiers in sports and active living2025
Effects of aerobic exercise on body composition and exerkines in colorectal cancer survivors.
Article in Frontiers in sports and active living, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03975491 (The Exercise And Colorectal Cancer Treatment), which is not on this map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Exercise And Colorectal Cancer Treatment (EXACT) Trial
Who cites it
3 citing papers in PubMed.
- Effects of a short-term multicomponent functional exercise program on the serum proteome: an exploratory study in hospitalized older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Trial
- Observational
- Impact of a Longer-Term Physical Activity Intervention on Inflammatory and Oxidative Stress Biomarkers in Older People with Metabolic Syndrome.Antioxidants (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Introduction: Physical activity improves immune competency and is associated with a lower rate of cancer recurrence in colorectal cancer survivors. However, the exact mechanisms underlying these improvements remain unclear. Exercise-derived cytokines (exerkines), particularly IL-7 and IL-15, are crucial in maintaining optimal immune health. This study investigated whether a 12-week structured exercise training intervention increases IL-7 and IL-15 in colorectal cancer survivors. Methods: Sixty colorectal cancer survivors were randomized to a moderate-intensity home-based aerobic exercise group (150 min/week) or a control group for 12 weeks. IL-7 and IL-15 were quantified using ELISA, and body composition was measured using dual-energy x-ray absorptiometry. Results: At baseline, participants treated with chemotherapy had lower IL-7 than those not treated with chemotherapy [-3.3 pg/ml (95% CI: -1.3, -5.4); Discussion: Aerobic exercise may improve immune function in colorectal cancer survivors by restoring IL-7 after chemotherapy and improving IL-15 by altering body composition. Clinical Trial Registration: [https://clinicaltrials.gov/study/NCT03975491], identifier [NCT03975491].
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Registered trials
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