ArticleOncology letters2025
Transcriptomic analyses unveil the mechanism of saikosaponin A in inhibiting human neuroblastoma SK-N-AS cells.
Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Neuroblastoma (NB) is the most common pediatric malignant neoplasm. Saikosaponin A (SSa), a compound with potential therapeutic effects against this disease, inhibits the proliferation, metastasis and invasion of NB cells. However, its molecular mechanism remains elusive. The present study examined changes in gene expression in SK-N-AS NB cells after SSa administration using RNA sequencing. Subsequently, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Search Tool for the Retrieval of Interacting Genes/Proteins were used to analyze the differentially expressed genes between the treatment and control groups. Quantitative PCR technology confirmed the expression of the identified critical genes. The results identified multiple significant biological processes, including 717 GO terms and 55 KEGG pathways, constructing a 96-gene protein-protein interaction network, with
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