ArticleHealth science reports2025
Is There Any Correlation Between Diffusion-Weighted Imaging and Histopathologic Findings of Meningioma? A Retrospective Study.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: Meningiomas are common CNS tumors, with grading critical for treatment. This study aimed to determine if diffusion-weighted imaging (DWI) correlates with histopathologic findings in meningioma, focusing on tumor grade, subtype, and Ki-67 index. Methods: This retrospective study included 68 patients with meningioma who underwent preoperative MRI with DWI. Tumor grade was determined using the WHO classification. DWI intensity was categorized as hyperintense, isointense, or hypointense relative to normal brain tissue. ADC values were measured, and diffusion restriction was defined as high signal intensity on DWI with low signal intensity on the ADC map. Histopathologic analysis assessed the Ki-67 proliferation index. Statistical analysis used ANOVA, Chi-square, univariable linear regression (β), and odds ratios (OR) via SPSS 17.0, with Results: The study included 68 patients with a mean age of 52.1 ± 15.6 years, mostly females (67.65%). Most tumors were grade 1 (73.5%) with male patients having higher tumor grades than females. Meningothelial was the most common subtype. DWI intensity correlated with tumor grade, with higher grades more likely to be hypointense. ADC values varied with tumor grades, being significantly higher in grade 1 tumors. Diffusion restriction was more common in higher-grade tumors. Ki-67 was higher in males ( Conclusion: Both qualitative DWI features and quantitative ADC values reflect meningioma grade and proliferative activity, with notable sex and subtype differences, underscoring the clinical utility of preoperative DWI.
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