A systematic quantification of hemodynamic differences persisting after aortic coarctation repair.

Introduction: Aortic coarctation (CoA) comprises 6%-8% of all congenital heart diseases and is the second most common cardiovascular disease requiring neonatal surgical correction. However, patients remain at high risk for long-term complications, notably recoarctation. Methods: Hemodynamic simulations were performed in a group of six patients following CoA repair, as compared to a group of age and sex-matched healthy controls. Progressive narrowing at the CoA repair site was modeled to simulate the recoarctation process. Key measurements included time-averaged wall shear stress (TAWSS) in the aortic arch and CoA repair site. Results: Repaired aortas demonstrated significantly higher TAWSS compared to healthy aortas in the aortic arch (3.46 vs 1.24 Pa, Discussion: The persistent high TAWSS in CoA-repaired aortas may underlie the poor long-term outcomes observed in this population. The identified nonlinear relationship between stenosis severity and TAWSS magnitude suggests a potential positive feedback mechanism, where abnormal shear stress exacerbates pathologic remodeling in the repaired aorta, highlighting the potential role of hemodynamic simulations in the clinical management of CoA patients.