Evidence map›Paper›PMID 40642483›Full record

ArticleEuropean heart journal open2025

The modified WHO class is associated with maternal complications in women with congenital heart disease.

Sara Jonsson, Bengt Johansson, Anna-Karin Wikström, Jenny Alenius Dahlqvist, Christina Christersson, Peder Sörensson, Aleksandra Trzebiatowska-Krzynska, Mikael Dellborg, Ulf Thilén, Inger Sundström-Poromaa and 1 more

Abstract read
In one paragraph

Article in European heart journal open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. ESC guidelines 2025 on cardiovascular disease and pregnancy: considerations and future perspectives.European heart journal supplements : journal of the European Society of Cardiology · 2026
    Article
  2. Article
  3. First quinquennium completed: highlights fromEuropean heart journal open · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sara JonssonDepartment of Public Health and Clinical Medicine, Umea University, 901 87 Umeå, Sweden.ORCID https://orcid.org/0009-0004-2690-2114
Bengt JohanssonDepartment of Diagnostics and Intervention, Umeå University, 901 87 Umeå, Sweden.ORCID https://orcid.org/0000-0003-0976-6910
Anna-Karin WikströmDepartment of Medical Sciences, Cardiology, Akademiska sjukhuset, 75185 Uppsala, Sweden.
Jenny Alenius DahlqvistDepartment of Clinical Sciences, Umea University, 901 87 Umeå, Sweden.
Christina ChristerssonDepartment of Women's and Childrens Health, Clinical Obstetric, Akademiska sjukhuset, 75185 Uppsala, Sweden.ORCID https://orcid.org/0000-0001-9116-8084
Peder SörenssonDepartment of Medicine, Solna, Karolinska Institutet, Karolinska University Hospital, 171 77 Stockholm, Sweden.ORCID https://orcid.org/0000-0001-5828-0015
Aleksandra Trzebiatowska-KrzynskaDepartment of Health, Medicine and Caring Sciences, Linköping University, 581 83 Linköping, Sweden.
Mikael DellborgDepartment of Molecular and Clinical Medicine, Bruna Stråket 16, 41345 Göteborg, Sweden.ORCID https://orcid.org/0000-0001-6502-8838
Ulf ThilénDepartment of Clinical Sciences, Lund University, BMC I12, 221 84 Lund, Sweden.
Inger Sundström-PoromaaDepartment of Medical Sciences, Cardiology, Akademiska sjukhuset, 75185 Uppsala, Sweden.
Annika BayDepartment of Nursing, Umea University, 901 87 Umeå, Sweden.ORCID https://orcid.org/0000-0001-6321-8240

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: With a growing population of women with congenital heart disease (CHD), pregnancies in this group are expected to increase. However, pregnancy in women with CHD is associated with increased adverse outcomes for both mother and child. The aim of this study was to evaluate pregnancy and foetal complications in women with CHD and to test their association with the modified WHO (mWHO) classification. Methods and results: Using two national registers, the national register for CHD and the Pregnancy Register, primiparous women giving birth between 2014 and 2019 were identified. Women with CHD, Conclusion: Pregnancy complications are more common in women with CHD. In women with CHD, the mWHO classification is associated with maternal complications and preterm birth. Thus, large national register data corroborate the advice provided in current guidelines, and the mWHO class is deemed a valuable risk stratification tool in women with CHD.

Indexed as

Adult congenital heart diseasemWHOPregnancy

Identifiers

PMID40642483
PMCPMC12241849

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.