Evidence map›Paper›PMID 40642463›Full record

ArticleRSC advances2025

Investigation of decellularized live hyaline cartilage graft material for efficient treatment of knee cartilage defects.

Mingdi Zheng, Junjie Jiang, Linyan Cong, Siye Li, Yunpeng Qu, Tao Sun, Gong Cheng

Abstract read
In one paragraph

Article in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mingdi ZhengDepartment of Orthopedics, Yantaishan Hospital, Yantai Key Laboratory for Repair and Reconstruction of Bone & Joint Yantai 246003 China sunt519@163.com jdgbdgg@126.com.
Junjie JiangDepartment of Orthopedics, Yantaishan Hospital, Yantai Key Laboratory for Repair and Reconstruction of Bone & Joint Yantai 246003 China sunt519@163.com jdgbdgg@126.com.
Linyan CongDepartment of Orthopaedics & Sports Medicine Department, Weihai Municipal Hospital Weihai 264200 China.
Siye LiDepartment of Hand Surgery, The No. 971 Hospital of People's Liberation Army Navy Qingdao Shandong Province 266000 China.
Yunpeng QuCollege of Physics, Guizhou University Guiyang 550025 China ypqu@gzu.edu.cn.ORCID https://orcid.org/0000-0002-7973-8555
Tao SunDepartment of Orthopedics, Yantaishan Hospital, Yantai Key Laboratory for Repair and Reconstruction of Bone & Joint Yantai 246003 China sunt519@163.com jdgbdgg@126.com.
Gong ChengDepartment of Orthopedics, Yantaishan Hospital, Yantai Key Laboratory for Repair and Reconstruction of Bone & Joint Yantai 246003 China sunt519@163.com jdgbdgg@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We first studied the structural morphology and thermal stability properties of decellularized live hyaline cartilage grafts (DLHCG) material, and further explored its short-term clinical efficacy in treating knee cartilage effects. The DLHCG material show good porous gel properties, excellent human compatibility, and chemical stability. We surgically implanted the DLHCG material into patients with articular cartilage defects and evaluated the effectiveness of its treatment using magnetic resonance imaging (MRI) as a characterization tool. This work proves that the DLHCG material can repair cartilage defects in the knee joint without adverse reactions in patients, and has good clinical application value.

Identifiers

PMID40642463
PMCPMC12242387

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.