Evidence map›Paper›PMID 40642444›Full record

ArticleEJHaem2025

Acute Lung Injury in a Healthy Peripheral Blood Stem Cell Donor Following Granulocyte-colony Stimulating Factor Administration: A Case Report.

Nihar Desai, Tommy Alfaro Moya, Michele Heffering-Cardwell, Felipe Tijmes Sanchez, Fotios V Michelis, Arjun Datt Law

Abstract read
In one paragraph

Article in EJHaem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nihar DesaiHans Messner Allogeneic Blood and Marrow Transplant Program Division of Medical Oncology and Hematology Princess Margaret Hospital Toronto Canada.
Tommy Alfaro MoyaHans Messner Allogeneic Blood and Marrow Transplant Program Division of Medical Oncology and Hematology Princess Margaret Hospital Toronto Canada.
Michele Heffering-CardwellHans Messner Allogeneic Blood and Marrow Transplant Program Division of Medical Oncology and Hematology Princess Margaret Hospital Toronto Canada.
Felipe Tijmes SanchezDepartment of Medical Imaging University of Toronto Toronto Canada.
Fotios V MichelisHans Messner Allogeneic Blood and Marrow Transplant Program Division of Medical Oncology and Hematology Princess Margaret Hospital Toronto Canada.ORCID https://orcid.org/0000-0003-2956-0848
Arjun Datt LawHans Messner Allogeneic Blood and Marrow Transplant Program Division of Medical Oncology and Hematology Princess Margaret Hospital Toronto Canada.ORCID https://orcid.org/0000-0002-9251-3609

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Granulocyte-colony stimulating factor (G-CSF) is routinely used for peripheral blood stem cells (PBSC) mobilization in healthy donors for allogeneic hematopoietic stem cell transplantation, with mild, transient adverse effects. Pulmonary complications are exceedingly rare in healthy donors. We report a case of acute lung injury in a healthy donor after G-CSF administration requiring hospitalization and treatment with corticosteroids. This case highlights the potential for rare but serious G-CSF-induced pulmonary toxicity, particularly in donors with predisposing factors such as obesity and smoking. Increased awareness of these rare adverse events is essential given the widespread use of G-CSF in PBSC mobilization.

Indexed as

allogeneic stem cell transplantation | G‐CSF | obesity | pulmonary toxicity | stem cell donor

Identifiers

PMID40642444
PMCPMC12244254

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.