ArticleFrontiers in psychiatry2025
Relationship between negative symptoms, cognitive function and social function in schizophrenia: new insight from a network analysis.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Reading body and face language in male schizophrenia.Schizophrenia (Heidelberg, Germany) · 2026Article
- The Impact of Humanistic Postoperative Care Integrated With the 6S Management Model on Postoperative Delirium and Psychiatric Symptoms in Patients With Schizophrenia Undergoing Surgery.Actas espanolas de psiquiatria · 2026Article
- Memory and learning impairments in deficit and non-deficit schizophrenia: a scoping review.Postepy psychiatrii neurologii · 2026Review
- Abnormal plasma oxidative stress markers in first-episode schizophrenia and associations with clinical symptoms and cognitive function.Schizophrenia (Heidelberg, Germany) · 2026Article
- The kynurenine pathway in depression and schizophrenia: convergent signals, divergent states, and clinical signatures.EXCLI journal · 2026Review
- The Moderating Role of Social Functioning in the Relationship Between Stigma and Quality of Life in Rural Chinese Patients with Schizophrenia: A Cross-Sectional Study.Neuropsychiatric disease and treatment · 2026Article
- The role of cognitive function in predicting metabolic risk in schizophrenia: a multi-model comparison incorporating clinical features.Frontiers in psychiatry · 2025Article
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Authors and funding
11 authors.
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Abstract
Objective: This study aimed to investigate the complex relationships between negative symptoms, cognitive function, and social functioning in chronic male patients with schizophrenia, identifying core symptoms to lay a theoretical foundation for targeted interventions aimed at negative symptoms in this population. Methods: A total of 161 male schizophrenia patients were included, categorized into deficit syndrome (DS) and non-DS groups using the Chinese version of the Schedule for the Deficit Syndrome (SDS). Social functioning was assessed with the Scale of Social Function in Psychosis Inpatients (SSPI), while a battery of neurocognitive tests measured cognitive domains, including sustained attention, cognitive flexibility, ideation fluency, and visuospatial memory. Network analysis was employed to construct an integrated network of negative symptoms, cognitive function, and social functioning, aiming to identify the most central and bridge symptoms within these networks. Results: Our study indicated that DS patients performed worser in cognitive function and social functioning than non-DS patients. The network analysis demonstrated that "intensity of pleasure during activities (B1)" in the negative symptoms was the most central node. The most prominent bridge node was SSPI, with impact indices of 0.55. Conclusion: Our findings provided evidence revealing a closer connection between negative symptoms, cognitive function, and social functioning. In light of these findings, precise targets for pharmacological treatment, psychotherapy and physical therapy are identified for patients with schizophrenia.
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