ArticleSaudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
Specific retinal vasculitis in HLA-A29 birdshot retinochoroiditis, distinguishing it from other causes of vasculitis: A pilot study.
Article in Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeHuman leukocyte antigen-A29 (HLA-A29) birdshot retinochoroiditis (BRC) is a noninfectious uveitis affecting independently the retina and the choroid. While the choroidal involvement is characterized by a stromal choroiditis, the retinal features of BRC were less well defined until a recent study determined a specific pattern of retinal involvement with seven features including profuse posterior retinal leakage, thick fluorescein angiography sheathing/staining, profuse disc hyperfluorescence, macular edema with foveal sparing, and circulatory arteriovenous pseudo delay. The aim of this study was to determine whether the specific pattern of retinal involvement was diagnostic for BRC distinguishing it from other causes of retinal vasculitis.
methodsA retrospective comparative study comparing patients diagnosed with BRC to patients with other causes of retinal vasculitis. A score based on seven retinal features was calculated. The maximum possible score was 16. If the score reached ≥ 9, the vasculitis was considered to be compatible with BRC.
resultsEighteen BRC and 18 non-BRC vasculitis were included in the study. The mean age of BRC patients was 49.5 ± 9.1 years, 11/18 females and 7/18 males (female 61%/male 39%). HLA-A29 antigen was present in all patients (100%). The mean age of patients in the control group with non-BRC vasculitis was 37 ± 17, 11/18 females and 7/18 males (female 61%/male 39%). The control group included nine cases of sarcoidosis chorioretinitis, six cases of intermediate uveitis of the pars planitis type, two cases of Behçet uveitis, and one case of tuberculosis chorioretinitis. The mean scores for the BRC group were 10.5 ± 1.7, while in the control group, it was 3.9 ± 2.8 (
conclusionRetinal vasculitis related to BRC has specific findings leading, if present, to the diagnosis of BRC that should be ascertained by the search of indocyanine green angiography lesions with the ultimate confirmation by the presence of the HLA-A29 antigen.
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