Evidence map›Paper›PMID 40642287›Full record

ArticleMaterials today. Bio2025

A non-swellable, anisotropic hydrogel patch with superior mechanical stability for internal anti-adhesion via physical barrier and inflammation regulation.

Jianyu Qiu, Xitong Kang, Tao Liu, Jing Liu, Huansheng Liu, Xiyang Zhao, Yong Li, Qi Liu, Zhenzhen Nong, Qingwen Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jianyu QiuInstitute of Biomass Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China.
Xitong KangInstitute of Biomass Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China.
Tao LiuCollege of Food Science, South China Agricultural University, Guangzhou, 510642, China.
Jing LiuInstitute of Biomass Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China.
Huansheng LiuInstitute of Biomass Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China.
Xiyang ZhaoInstitute of Biomass Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China.
Yong LiInstitute of Biomass Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China.
Qi LiuCollege of Food Science, South China Agricultural University, Guangzhou, 510642, China.
Zhenzhen NongCollege of Food Science, South China Agricultural University, Guangzhou, 510642, China.
Qingwen WangInstitute of Biomass Engineering, College of Materials and Energy, South China Agricultural University, Guangzhou, 510642, China.
Zhenzhen LiuThe Third Affiliated Hospital, School of Biomedical Engineering, Guangzhou Medical University, Guangzhou, 511436, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tension-free repair operation in clinic needs an implantable mesh to repair the internal soft-tissue defect. However, the clinical patches fail to simultaneously achieve anti-adhesion, anti-deformation and tissue pro-healing. Herein, a high-performance anti-adhesion hydrogel patch is synthesized by one-step of directed freeze-casting technique via utilizing the FDA-approved poly (vinyl alcohol) (PVA) and carboxymethylcellulose nanofibril (CNF) as the network backbone without any chemical crosslinker. This fully physical crosslinked hydrogel exhibits remarkable mechanical performance because of the highly oriented microstructure and multiple hydrogen bonding, including the matching mechanical property with soft tissue, anti-tearing capability, the great 99 % retention of tensile stress and higher toughness after soaking at PBS for 7 days. And the extremely low swelling ratio of 5.9 % in PBS and combining the higher water-content is superior to other reported anti-swelling hydrogel. Importantly, besides as a robust physical barrier of this hydrogel patch, it also displays the excellent inflammatory regulation via capturing the positively charged proinflammatory cytokines because of the incorporation of the negatively charged CNF, synergistically promoting the remarkable anti-adhesion and tissue pro-healing efficiency. By integrating the anti-adhesion, tissue pro-healing, long-lasting anti-deformation in vivo and excellent bio-compatibility, this hydrogel provides a great candidate of anti-adhesion patch for tension-free repair operations.

Indexed as

Anti-adhesion hydrogelAnti-swellingInflammatory regulationPost-operative adhesionTissue pro-healing

Identifiers

PMID40642287
PMCPMC12241401

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.