ArticleFrontiers in public health2025
Positive and linear association of hepatic steatosis index with female infertility in US women: results from the National Health and Nutrition Examination Survey 2013-2018.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Decoding the potential association of liver steatosis with female infertility: an analysis from NHANES 2013-2018.BMC public health · 2025Article
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3 authors.
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Abstract
Background: Female infertility is a global reproductive health challenge. The hepatic steatosis index (HSI) is a simple and non-invasive screening tool for steatosis. We herein explore the association of HSI with female infertility through the National Health and Nutrition Examination Survey (NHANES) 2013-2018. Methods: This cross-sectional study included 2,133 reproductive-age women from 15 U.S. states, with data collected through standardized questionnaires, physical examinations, and laboratory tests across three survey cycles (2013-2018). HSI was assessed based on body mass index, ALT/AST, sex, and diabetes status. Female infertility status was ascertained through standardized questionnaire items reflecting clinical diagnostic criteria (≥1 year of unprotected intercourse without conception), though not verified by medical records or fertility testing. Multivariable logistic regression analysis was used to explore the association between HSI and female infertility and to calculate the odds ratio (OR) and 95% confidence interval (CI). Restricted cubic spline (RCS) and stratified analyses were further employed to examine potential nonlinear relationships and subgroup disparities. Explored the factors affecting HSI through multivariate analysis. Results: A total of 2,133 reproductive-age women were enrolled, of whom 271 had infertility. There was no significant trend in HSI levels across cycles. In the fully adjusted model, HSI showed positive cross-sectional associations with self-reported infertility status (OR 1.02, 95% CI 1.01-1.04, Conclusion: HSI was positively associated with the odds of female infertility and demonstrated a linear dose-response association. These findings suggest that HSI may be used as an potential marker to screen reproductive age women at high risk of infertility, although further research is needed to validate its predictive utility and clinical applicability.
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