ArticleFrontiers in neurology2025
Unsupervised machine learning revealed a correlation between low-dose statins and favorable outcomes in ICH patients.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Prehospital intensive blood pressure management in intracerebral hemorrhage: current evidence, controversies, and future directions.Frontiers in medicine · 2026Review
- Predictive modeling of brain herniation risk factors and critical thresholds in spontaneous intracerebral hemorrhage: a pilot study.Frontiers in neurology · 2025Article
- Anticoagulation management in intracerebral hemorrhage patients with deep vein thrombosis: insights from unsupervised machine learning and nomogram analysis.Frontiers in neurology · 2025Article
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Authors and funding
4 authors.
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Abstract
Background: Statins were effective in preventing ischemic stroke in patients with intracerebral hemorrhage (ICH). Statins administered at normal doses may contribute to hematoma expansion. We employed unsupervised machine learning methods and found that low-dose statins improve the prognosis of ICH. Methods: We employed unsupervised machine learning techniques to analyze unidentified factors within a retrospective cohort related to the prognosis of ICH. In our prospective cohort study, data were gathered from ICH patients over a three-year period. Outcomes included mortality, cerebrovascular events within 3 years, unfavorable functional outcomes at 3 months, and hematoma expansion during hospitalization. Results: The heatmap illustrated distinct statin effect trajectories, emphasizing the substantial impact of low-dose statins on prognosis. The low-dose statin group exhibited reduced mortality ( Conclusion: Unsupervised machine learning revealed a correlation between low-dose statins and patient prognosis. Subsequent analyses and validation indicated that for patients with intracerebral hemorrhage (ICH) in the cerebral hemisphere, early administration of low-dose hydrophilic statins is associated with reduced mortality, and statins are associated with a reduced rate of ischemic stroke occurrence. For all ICH patients, low-dose statins are associated with a lower rate of unfavorable functional outcomes but show no significant association with hematoma expansion.
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