ArticleFrontiers in nutrition2025
Pesticide exposure and cardiovascular health in non-CVD mortality population: novel evidence from NHANES 2007-2018 using Life's Essential 8.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Translational Gaps in Assessing the Obesogenic Effects of Herbicides: A Scoping Review.Journal of xenobiotics · 2026Review
- Community Health Impacts of Pesticide Exposure: Pathways, Vulnerable Populations, and Public Health Responses.International journal of environmental research and public health · 2026Review
- Pesticides Drive Liver Diseases Through Non-Apoptotic Regulated Cell Death Pathways.Diseases (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: While pesticide exposure has become a global public health concern, its impact on cardiovascular health among non-cardiovascular mortality populations remains understudied. Methods: Based on NHANES 2007-2018 data ( Results: 2,4-D herbicides showed significant negative correlations with multiple LE8 components, particularly in BMI scores (β = -1.441, 95% CI: -2.158, -0.725) and diet scores (β = -1.241, 95% CI: -1.825, -0.658). Organophosphate metabolites demonstrated positive associations with smoking and diet scores. Dose-response analysis revealed an inverted U-shaped relationship between 2,4-D and LE8 scores, while organophosphates showed consistent positive correlations. WQS regression indicated that glyphosate contributed most significantly to LE8 scores (58%), while organophosphate diethyl metabolites dominated CMI effects (62%). Inflammatory markers (CRP and SII) played crucial roles in mediating pesticide exposure's effects on cardiovascular health. Conclusion: This study provides the first systematic evidence of association patterns between pesticide exposure and cardiovascular health in the general population, revealing differential impacts across pesticide types. These findings provide important scientific basis for understanding pesticide exposure's health effects and developing targeted prevention strategies.
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