ArticlePatient preference and adherence2025
The Pendulum of Adherence: An Interpretative Phenomenological Analysis of Psoriasis Treatment Discontinuation.
Article in Patient preference and adherence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- TRIM28 Promotes Keratinocyte Proliferation and Invasion by Activating NLRP3/SGT1 Axis-Mediated Macrophage Pro-Inflammatory Polarization in an In Vitro Macrophage-Keratinocyte Co-Culture Model.Immunity, inflammation and disease · 2026Article
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Authors and funding
5 authors.
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Abstract
Background: Psoriasis is a chronic, immune-mediated skin disorder requiring lifelong management, yet maintaining treatment adherence remains a significant challenge. Frequent treatment discontinuation often results in disease recurrence and poorer health outcomes, highlighting the need for a comprehensive understanding of psoriasis patients' lived experiences concerning treatment adherence. Methods: A phenomenological research approach was employed to explore psoriasis patients' lived experiences concerning treatment adherence. Semi-structured, in-depth interviews were conducted with 16 participants, all discontinued and later resumed treatment. Data were analyzed using interpretative phenomenological analysis (IPA) to identify key themes shaping treatment adherence. Bronfenbrenner's Process-Person-Context-Time (PPCT) model was also applied to elucidate the underlying mechanisms influencing treatment adherence. Results: Findings revealed four Group Experiential Themes (GETs) associated with treatment discontinuation: Healthcare Instability, Loss of Faith in Treatment, Financial Strain, and Concerns About Side Effects. Five GETs emerged as motivators for resuming treatment: Hope in New Therapies, Stigma and Social Pressure, Severe Symptom Relapse, Financial Relief, and Support from Healthcare Professionals. Conclusion: This study systematically uncovers the complex factors influencing psoriasis treatment adherence. Applying phenomenology and the PPCT model illustrates the dynamic interplay between individual and environmental influences that shape psoriasis patients treatment adherence. A patient-centred, community-based, and adaptive approach is essential to bridging the gap between clinical recommendations and real-world treatment adherence, thereby improving long-term disease management and enhancing psoriasis patients' quality of life.
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