ReviewJournal of clinical orthopaedics and trauma2025
Impact of early weight-bearing on outcomes of femur fractures treated with intramedullary nailing: A systematic review and meta-analysis.
Review in Journal of clinical orthopaedics and trauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
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Abstract
Early weight-bearing (EWB) following intramedullary nailing (IMN) for femur fractures remains a debated topic. This systematic review and meta-analysis, registered with PROSPERO (CRD42025639691) and conducted in accordance with PRISMA guidelines, aimed to evaluate the impact of EWB versus delayed weight-bearing (DWB) on functional recovery, radiographic union, and complications. A literature search across PubMed, Cochrane, and Scopus identified three eligible studies comprising 537 adult patients. The analysis revealed no statistically significant differences between EWB and DWB groups in radiographic union rates, nonunion rates, or implant failure. Radiographic union was nearly identical across groups (RR = 1.00, 95 % CI: 0.96-1.05), with nonunion (RR = 1.10, 95 % CI: 0.68-1.79) and implant failure (RR = 1.95, 95 % CI: 0.55-6.87) also showing no significant differences. Sensitivity analyses, including exclusion of a moderate-quality study and model comparisons, confirmed the robustness of these findings. Most included studies were of high methodological quality. According to the GRADE framework, evidence certainty was moderate for radiographic union but low to very low for complications. While early mobilization may be safe and beneficial, further high-quality prospective trials are needed to strengthen these conclusions.
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Registered trials
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