ReviewResearch (Washington, D.C.)2025
The Functions and Mechanisms of the Cohesin Complex in Regulating the Fate Determinations of Stem Cells.
Review in Research (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- SMC1A is required for fate determinations of human spermatogonial stem cells and male fertility by interacting with YBX1 and stabilizing HMGA2 mRNA via an mCell death and differentiation · 2026Article
- Metabolic profiling and perturbations of human CD34+ hematopoietic stem and progenitor cells to regulate HSPC function.Blood advances · 2026Article
- Microproteins in Human Physiology and Pathology.Biochemistry · 2026Review
- Chromatin remodeling and epigenetic regulation of mesenchymal stem/stromal cells in osteoarthritis.Frontiers in genetics · 2026Review
- Co-Occurrence ofInternational journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stem cells have important applications in both regenerative and reproductive medicine. The cohesin complex comprises 4 core subunits, namely, SMC1, SMC3, RAD21, and STAG, and notably, it plays pivotal roles in controlling the fate determinations of stem cells by facilitating the dynamic regulation of the 3-dimensional genome architecture. We have recently reported that RAD21 forms a complex with YAP1 and NEDD4 to promote the self-renewal of human spermatogonial stem cells and inhibit their apoptosis. In this review, we address the molecular properties of the cohesin complex and its multiple regulatory mechanisms in mediating the fate decisions of various kinds of stem cells, including hematopoietic stem cells, embryonic stem cells, spermatogonial stem cells, neural stem cells, and other types of stem cells. By maintaining the chromatin loop structure, the cohesin complex is involved in DNA repair and gene transcription, which in turn controls the pluripotency, self-renewal, and differentiation of stem cells. In addition, the cohesin complex ensures faithful DNA replication and sister chromatid cohesion, which indirectly supports genetic and epigenetic programs. Variants in the subunit components of the cohesin complex and proteins' modifications further confer functional plasticity, and its mutations can lead to abnormal stem cell functions and are correlated with diseases including cancers. Future studies need to integrate multidisciplinary approaches including single-cell multi-omics and cryo-electronic microscopy to resolve the dynamic regulatory networks of the cohesin complex in stem cell fate regulation and further explore its potential applications in regenerative and reproductive medicine.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.