Evidence map›Paper›PMID 40641988›Full record

ReviewBiomaterials translational2025

Research progress on the role and mechanism of magnesium-containing materials in bone repair.

Yuanchao Zhu, Junyu Su, Tiantian Qi, Geng Zhang, Peng Liu, Haotian Qin, Qi Yang, Sen Yao, Yien Zheng, Jian Weng and 2 more

Abstract readReview
In one paragraph

Review in Biomaterials translational, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. [Microenvironmental dysregulation and advances in functional biomaterial-based interventions for diabetic bone defect repair].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuanchao ZhuSchool of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen, Guangdong Province, China.
Junyu SuSchool of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen, Guangdong Province, China.
Tiantian QiDepartment of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.
Geng ZhangDepartment of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.
Peng LiuNational & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.
Haotian QinDepartment of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.
Qi YangDepartment of Ultrasonography, Peking University Shenzhen hospital, Shenzhen, Guangdong Province, China.
Sen YaoDepartment of Orthopedics, Shenzhen Yantian District People's Hospital, Shenzhen, Guangdong Province, China.
Yien ZhengInstitute for Macromolecular Chemistry, University of Freiburg, Freiburg, Germany.
Jian WengDepartment of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.
Hui ZengDepartment of Orthopedics, Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China.
Fei YuDepartment of Bone & Joint Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bones can fulfill functions in movement, attachment, and protection of internal organs. Bone diseases caused by ageing, trauma, infection, and other reasons may seriously affect the daily life of patients. Magnesium ions are closely associated with the maintenance of bone health. Integrating magnesium ions into delivery systems and hydrogels can improve their application, thus directly acting on the osteoblast cell lineage and influencing the proliferation and differentiation of relevant cells. The slow release of magnesium ions allows for their effects on the target site for a long time, reducing the clearance of magnesium ions in the body, which significantly contributes to bone repair. Magnesium-based bioalloy scaffolds have received widespread attention for their favourable biocompatibility, degradability, and bone-forming properties and play an important role in bone regeneration and repair. This article presents a review on the role and mechanism of magnesium-containing materials in bone repair and regeneration. By discussing the current challenges and future directions for magnesium-containing biomaterials, new insights are provided into the development of these materials in the field of orthopaedics. In conclusion, magnesium-containing biomaterials have great application value in orthopaedics.

Indexed as

Bone repairDelivery systemMagnesium-based bioalloy scaffoldsMagnesium ionsMagnesium-loaded hydrogels

Identifiers

PMID40641988
PMCPMC12237806

What OpenQuestion holds

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LicenceCC BY-NC-SA
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.