ArticleFrontiers in medicine2025
Tissue-engineered tubular substitutions for urinary diversion in a preclinical rabbit model.
Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The engineered bladder patch with a three-layer structure promotes the regeneration and functional recovery of the bladder in a rabbit model.Bioengineering & translational medicine · 2026Article
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Authors and funding
2 authors.
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Abstract
Objective: To develop and evaluate tissue-engineered tubular constructs using homologous adipose-derived stem cells (ASCs), smooth muscle cells (SMCs), and decellularized fish swim bladder (DFSB) matrix for urinary diversion in a rabbit model. Methods: Rabbit ASCs and SMCs were isolated and expanded Results: All experimental animals survived until scheduled sacrifice with histological evidence of: (1) luminal multilayer urothelium, (2) organized smooth muscle tissue on abluminal surfaces, and (3) construct-wide neovascularization of varying diameters; IVU confirmed absence of urinary leakage, stricture, or obstruction. Conversely, all control animals died within 2 weeks post-operation; autopsy revealed urine leakage, extensive scar formation, and severe inflammation as mortality causes. Conclusion: Tissue-engineered tubular constructs fabricated from homologous ASCs, SMCs, and DFSB scaffold demonstrate feasibility as a viable urinary diversion alternative in rabbit models, showing functional tissue regeneration and superior outcomes versus acellular controls.
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