Evidence map›Paper›PMID 40641923›Full record

ArticleFrontiers in oncology2025

Risk factors and outcome of asparaginase-associated pancreatitis in pediatric acute lymphoblastic leukemia.

Seham Hassan, Sonia Ahmed, Nesreen Ali, Abeer Mokhles, Iman Zaky, Hala Reda, Sarah H Youssef, Dina Hammad, Omneya Hassanain, Iman Sidhom

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Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Seham HassanPediatric Oncology Department, Children's Cancer Hospital Egypt, Cairo, Egypt.
Sonia AhmedPediatric Oncology Department, National Cancer Institute, Cairo University, and Children's Cancer Hospital Egypt, Cairo, Egypt.
Nesreen AliPediatric Oncology Department, National Cancer Institute, Cairo University, and Children's Cancer Hospital Egypt, Cairo, Egypt.
Abeer MokhlesClinical Oncology Department, Beni-Suef University, Egypt and Children's Cancer Hospital Egypt, Cairo, Egypt.
Iman ZakyRadiology Department, National Cancer Institute, Cairo University, and Children's Cancer Hospital Egypt, Cairo, Egypt.
Hala RedaClinical Pathology Department, National Cancer Institute, Cairo University, and Children's Cancer Hospital Egypt, Cairo, Egypt.
Sarah H YoussefDepartment of Pharmaceutical Services, Children's Cancer Hospital Egypt, Cairo, Egypt.
Dina HammadDepartment of Pharmaceutical Services, Children's Cancer Hospital Egypt, Cairo, Egypt.
Omneya HassanainClinical Research Department, Children's Cancer Hospital Egypt (57357), Cairo, Egypt.
Iman SidhomPediatric Oncology Department, National Cancer Institute, Cairo University, and Children's Cancer Hospital Egypt, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Asparaginase-associated pancreatitis (AAP) poses a significant challenge in pediatric patients with acute lymphoblastic leukemia (ALL), with its severity ranging from mild cases to potentially life-threatening conditions. Aim: To study the incidence, risk factors of AAP, and its impact on outcome in pediatric ALL patients in a large pediatric oncology hospital in a low-and middle-income country. Patient and methods: This retrospective study included 1804 pediatric patients newly diagnosed with ALL at a single tertiary care center from June 2012 to December 2017. They were treated with ALL protocol adopted from St Jude total study XV including native E. coli L-asparaginase. Results: Sixty-three (3.5%) patients experienced AAP. Age ≥10 years at diagnosis, initial white blood cell count (WBC) ≥50x10 Conclusion: Older age and high-dose asparaginase regimens are independent risk factors of AAP. The decision to re-challenge asparaginase should be carefully considered balancing the risk of recurrent pancreatitis against the potential risk of leukemic relapse.

Indexed as

acute lymphoblastic leukemiaasparaginaselow and middle-income countriespancreatitispediatricrisk factors

Identifiers

PMID40641923
PMCPMC12241112

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.