Evidence map›Paper›PMID 40641742›Full record

ReviewBiochemistry and biophysics reports2025

Natural product-based inhibitors of quorum sensing: A novel approach to combat antibiotic resistance.

Esther Ugo Alum, Bashar Haruna Gulumbe, Sylvester Chibueze Izah, Daniel Ejim Uti, Patrick Maduabuchi Aja, Ikechuku Okorie Igwenyi, Christian Emeka Offor

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemistry and biophysics reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed.

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  18. Molecular Mechanisms Underlying the Pathogenicity ofMedicina (Kaunas, Lithuania) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Esther Ugo AlumDepartment of Research Publications, Kampala International University, Main Campus, P. O. Box 20000, Kampala, Uganda.
Bashar Haruna GulumbeDepartment of Microbiology, Faculty of Science, Federal University Birnin Kebbi, PMB 1157, Birnin Kebbi, Kebbi State, Nigeria.
Sylvester Chibueze IzahDepartment of Community Medicine, Faculty of Clinical Sciences, Bayelsa Medical University, Yenagoa, Bayelsa State, Nigeria.
Daniel Ejim UtiDepartment of Research Publications, Kampala International University, Main Campus, P. O. Box 20000, Kampala, Uganda.
Patrick Maduabuchi AjaDepartment of Biochemistry, Ebonyi State University, Abakaliki, Nigeria.
Ikechuku Okorie IgwenyiDepartment of Biochemistry, Ebonyi State University, Abakaliki, Nigeria.
Christian Emeka OfforDepartment of Biochemistry, Ebonyi State University, Abakaliki, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global rise of antibiotic resistance (AR) presents a critical threat to public health, prompting the search for innovative antimicrobial strategies. Quorum sensing (QS), a bacterial communication system that governs virulence, biofilm formation, and resistance, has emerged as a compelling non-lethal therapeutic target. This review explores the potential of natural product-based quorum sensing inhibitors (QSIs) derived from plants, microbes, and marine organisms. These compounds disrupt QS pathways through various mechanisms, including inhibition of signal synthesis, receptor antagonism, enzymatic degradation of signaling molecules, and suppression of QS-regulated gene expression. Particular emphasis is placed on the molecular targets and synergistic potential of natural QSIs when combined with conventional antibiotics to enhance efficacy and curb resistance development. This narrative review explores the diverse sources of natural QSIs, including plant-derived phytochemicals, microbial secondary metabolites, and marine bioactive compounds. In this study, a thorough literature search was conducted using databases such as PubMed, Scopus, Web of Science, and Google Scholar. Studies selected were those published between 2013 and 2025 in peer-reviewed journals. The manuscript also examines translational challenges such as poor bioavailability, bacterial adaptability, and regulatory barriers, alongside innovative strategies including nanoparticle-based delivery and combination therapies. Finally, clinical and industrial applications of QSIs are discussed, reinforcing their promise as sustainable tools for combating resistant infections and biofilm-associated diseases. This review underscores QS inhibition as a transformative approach in the ongoing battle against antibiotic resistance.

Indexed as

Antibiotic resistanceAntimicrobial therapyBacterial communicationBiofilm inhibitionNatural productsQuorum sensing inhibitors

Identifiers

PMID40641742
PMCPMC12242448

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.