Evidence map›Paper›PMID 40641678›Full record

ArticleTranslational exercise biomedicine2025

Association of circulating Notch1 and VEGF with flow-mediated dilation and aerobic fitness in healthy adults.

Brooke R Shepley, Nick J Lester, Lana H Yacoub, Anthony R Bain

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational exercise biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Brooke R ShepleyDepartment of Kinesiology, Faculty of Human Kinetics, University of Windsor, Windsor, ON, Canada.ORCID https://orcid.org/0009-0002-5111-3286
Nick J LesterDepartment of Kinesiology, Faculty of Human Kinetics, University of Windsor, Windsor, ON, Canada.
Lana H YacoubDepartment of Kinesiology, Faculty of Human Kinetics, University of Windsor, Windsor, ON, Canada.
Anthony R BainDepartment of Kinesiology, Faculty of Human Kinetics, University of Windsor, Windsor, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Notch1 is a mechanosensitive endothelial receptor that responds to vascular wall shear stress. However, data on Notch1 activity in humans remains limited, particularly regarding its role in endothelial function. Objectives: Accordingly, the purpose of this study was to determine whether Notch1 is associated with the flow-mediated dilatory (FMD) response and whether it is related to aerobic fitness. A secondary purpose was to determine whether Notch1 is related to concentrations of vascular endothelial growth factor (VEGF). Methods: Sixteen (8M/8F) young (20-30 yrs old) and healthy (BMI: 25 ± 4.2 kg/m Results: In contrast to our hypothesis, concentrations of NECD and VEGF did not change throughout the FMD and were unrelated to allometrically scaled FMD values (p all>0.05). Likewise, there was no relationship between changes in NECD and VEGF (p=0.331, r=0.127). However, the change in NECD across the FMD was moderately (r=0.515) and significantly (p=0.024) correlated with V̇O Conclusions: These novel data indicate that in healthy young adults, Notch1 activity is linked to aerobic fitness but may not be acutely involved in the shear-mediated vasodilatory response.

Indexed as

flow-mediated dilationmechanotransductionNotch1vascular endothelial growth factorvascular functionV̇O2 peak

Identifiers

PMID40641678
PMCPMC12239093

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.