SynthesisFrontiers in neuroscience2025
The clinical relevance of healthy neurodevelopmental connectivity in childhood and adolescence: a meta-analysis of resting-state fMRI.
Synthesis in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- Aberrant Resting-State Functional Connectivity Associated With Callous-Unemotional Traits From Late Childhood Through Late Adolescence.Biological psychiatry global open science · 2026Article
- Functional brain network correlates of pubertal timing and depressive symptoms in preadolescence.bioRxiv : the preprint server for biology · 2026Article
- Hidden Rhythms of a Developing Brain: Multimetric rs-fMRI Insights Into Typical Youth Maturation.Human brain mapping · 2025Article
- Functional reorganization of brain networks from childhood to adolescence: A multi-level approach.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In recent years, interest has grown in brain connectivity during infancy and adolescence, particularly in understanding neurodevelopment. Research is focusing on how brain network complexity evolves, providing insight into developmental neural connectivity. While some studies highlight key periods of brain maturation, findings remain inconsistent, leaving the neural correlates of typical development uncertain. This meta-analysis aims to identify brain regions and functional connectivity networks that show age-related activation patterns. Our goal is to clarify how neural wiring and complexity change with age, using seed-based d mapping (SDM) to analyze resting-state functional connectivity. Methods: We reviewed studies employing resting-state functional magnetic resonance imaging (rs-fMRI) to examine brain connectivity in typically developing children and adolescents. After thoroughly application of the rigorous inclusion criteria, five studies published between 2013 and 2024 remained selected for this analysis. While this is a small number, this limitation reflects our unwavering commitment to methodological rigor and the current scarcity of available literature, ensuring that only high-quality studies were considered. Results: Consistent increases in seed-based connectivity involving the left frontal and prefrontal cortices were observed, particularly the left superior frontal gyrus and bilateral anterior cingulate cortex. These areas showed increased connectivity in older compared to younger participants. Conclusion: The left frontal and prefrontal cortices, which are critical for executive function, attention, and intelligence, appear to strengthen their connectivity during childhood and adolescence. These observations provide a preliminary glimpse into typical brain maturation. However, due to the small number of studies and heterogeneity in age comparisons. No clinical implications can be drawn at this stage, and further research is required to confirm these developmental trends.
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