Evidence map›Paper›PMID 40641557›Full record

ArticleiScience2025

Therapeutic restoration of miR-96 prevents hearing loss in mice through modulation of noise-induced and genetic pathways.

Ruilong Xia, Chenxi Jin, Siying Fei, Tingting Dong, Ting Wen, Fengting Zhu, Yunxin Shi, Qian Zhou, Yong Tao, Changgeng Peng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ruilong XiaShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, Clinical Center For Brain and Spinal Cord Research, School of Medicine, Tongji University, Shanghai 200434, China.
Chenxi JinDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No.639, Zhizaoju Road, Shanghai 200011, P.R. China.
Siying FeiShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, Clinical Center For Brain and Spinal Cord Research, School of Medicine, Tongji University, Shanghai 200434, China.
Tingting DongBiobank of Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ting WenShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, Clinical Center For Brain and Spinal Cord Research, School of Medicine, Tongji University, Shanghai 200434, China.
Fengting ZhuShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, Clinical Center For Brain and Spinal Cord Research, School of Medicine, Tongji University, Shanghai 200434, China.
Yunxin ShiShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, Clinical Center For Brain and Spinal Cord Research, School of Medicine, Tongji University, Shanghai 200434, China.
Qian ZhouThe First Rehabilitation Hospital of Shanghai, No. 349 Hangzhou Road, Shanghai 200090, P.R. China.
Yong TaoDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No.639, Zhizaoju Road, Shanghai 200011, P.R. China.
Changgeng PengShanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People's Hospital, Clinical Center For Brain and Spinal Cord Research, School of Medicine, Tongji University, Shanghai 200434, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hearing loss often arises from impairments in multiple genes, complicating therapeutic development. MicroRNAs, as master regulators, offer promising targets for complex diseases. We explored

Indexed as

Cell biologyMolecular biologySensory neuroscience

Identifiers

PMID40641557
PMCPMC12245441

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.