Evidence map›Paper›PMID 40641552›Full record

ArticleiScience2025

Humanized mouse model reveals T cell ANXA2 as a potential therapeutic target in ischemic stroke.

Tianyuan Zhang, Xiaojuan Zheng, Aijun Lu, Shuyuan Li, Keshen Li, Xiaoxiong Huang, Yanfang Liu, Wei Chen, Shengming Huang, Niu He and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tianyuan ZhangDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Xiaojuan ZhengDepartment of Dermatology, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Aijun LuDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Shuyuan LiDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Keshen LiClinical Neuroscience Institute, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Xiaoxiong HuangDepartment of Neurology and Stroke Center, The Central Hospital of Shaoyang, Shaoyang 422099, China.
Yanfang LiuDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Wei ChenDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Shengming HuangDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Niu HeDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Chi Kwan TsangClinical Neuroscience Institute, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Hongcheng MaiDepartment of Neurology, Sun Yat-Sen MemorialHospital, Sun Yat-Sen University, Guangzhou 510120, China.
Anding XuDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.
Dan LuDepartment of Neurology and Stroke Center, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke T cell studies in rodents have not been translated to human studies. The mechanism of cellular and molecular T cells changes after stroke remains incompletely understood. Thus, this study established a humanized mouse model after middle cerebral artery occlusion (MCAO) and identifies potential therapeutic targets of humanized T cell populations. Similar to patients with stroke, a proportion of T cells was decreased in peripheral blood of humanized T cell stroke mice. Using single-cell RNA sequencing (scRNA-seq), we identified Annexin A2 (ANXA2) as biomarker of humanized T cell subsets in MCAO, which was validated using human ischemic brain and peripheral blood. With small-molecule inhibitors Leu-Cys-Lys-Leu-Ser-Leu (LCKLSL), ANXA2 inhibition altered T

Indexed as

Model organismMolecular neuroscience

Identifiers

PMID40641552
PMCPMC12245446

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.