Evidence map›Paper›PMID 40641435›Full record

ArticleJournal of proteome research2025

Proteomic Profiling of Acoustically Isolated Extracellular Vesicles from Blood Plasma during Murine Bacterial Sepsis.

Axel Broman, Yashuan Chao, Oonagh Shannon, Thomas Laurell, Johan Malmström

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of proteome research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Axel BromanDepartment of Biomedical Engineering, Lund University, Lund 222 42, Sweden.ORCID 0000-0002-2500-701X
Yashuan ChaoDivision of Infection Medicine, Department of Clinical Sciences, Lund University, Lund 222 42, Sweden.
Oonagh ShannonSection of Oral Biology, Faculty of Odontology, Malmö University, Malmö 205 06, Sweden.
Thomas LaurellDepartment of Biomedical Engineering, Lund University, Lund 222 42, Sweden.
Johan MalmströmDivision of Infection Medicine, Department of Clinical Sciences, Lund University, Lund 222 42, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis is a life-threatening condition caused by a dysregulated host response to an infection and is a leading cause of death worldwide. The condition is variable, which in combination with insufficient clinical markers, makes it challenging to predict when infection will progress to sepsis and to categorize patients into homogeneous patient subgroups. In this study, we demonstrate the use of acoustic trapping to rapidly enrich extracellular vesicles (EVs) from minute volumes of blood plasma from experimental mouse models of sepsis infected with the Gram-positive pathogen

Indexed as

Escherichia coli InfectionsExtracellular VesiclesProteomeProteomicsSepsisStreptococcal InfectionsAcousticsAnimalsDisease Models, AnimalEscherichia coliMass SpectrometryMiceMice, Inbred C57BLStreptococcus pyogenesProteomeacoustic trappingextracellular vesiclesmass spectrometryproteomicssepsis

Identifiers

PMID40641435
PMCPMC12322956

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.