Evidence map›Paper›PMID 40641341›Full record

ArticleBrain and behavior2025

Application of Serum NADPH Oxidase 2 Levels for Predicting 180-Day Clinical Outcomes Following Severe Traumatic Brain Injury: A Prospective Cohort Analysis.

Chang Su, Dapu Shen, Junlong Xu, Miaomiao Chen, Heng He, Jianping Ye

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Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Chang SuDepartment of Neurosurgery, Lishui Hospital of Wenzhou Medical University, Lishui City People's Hospital, Lishui, Zhejiang Province, China.
Dapu ShenDepartment of Neurosurgery, Lishui Hospital of Wenzhou Medical University, Lishui City People's Hospital, Lishui, Zhejiang Province, China.
Junlong XuDepartment of Intensive Care Unit, Lishui Hospital of Wenzhou Medical University, Lishui People's Hospital, Lishui, Zhejiang Province, China.
Miaomiao ChenDepartment of Intensive Care Unit, Lishui Hospital of Wenzhou Medical University, Lishui People's Hospital, Lishui, Zhejiang Province, China.
Heng HeDepartment of Neurosurgery, Lishui Hospital of Wenzhou Medical University, Lishui City People's Hospital, Lishui, Zhejiang Province, China.
Jianping YeDepartment of Intensive Care Unit, Lishui Hospital of Wenzhou Medical University, Lishui People's Hospital, Lishui, Zhejiang Province, China.ORCID https://orcid.org/0009-0009-5327-720X

Funding

City-level public welfare technology application research project of Lishui 2022GYX24City-level public welfare technology application research project of Lishui 2023SJZC078City-level public welfare technology application research project of Lishui 2023SJZC101City-level public welfare technology application research project of Lishui 2024GYX69Medical and Health Research Project of Zhejiang Province 2023XY260Medical and Health Research Project of Zhejiang Province 2025KY1969Medical and Health Research Project of Zhejiang Province 2025KY1970
6 · The paper itself

Abstract

objectivesNicotinamide adenine dinucleotide phosphate oxidase 2 (NOX2) affects oxidative response to acute brain injury. We set out to determine if there are connections between serum NOX2 levels, severity, and subsequent clinical outcomes of severe traumatic brain injury (sTBI).

methodsIn this prospective cohort study, serum NOX2 levels were measured in 123 patients and 123 controls. The Glasgow Coma Scale (GCS) scores and Rotterdam computed tomography (CT) classifications were applied for assessing injury severity. A poor prognosis was considered if the Glasgow Outcome Scale Extended (GOSE) score was 4 or below at 180 days post-injury.

resultsSTBI patients exhibited markedly enhanced serum NOX2 levels relative to healthy controls, and serum NOX2 levels were independently linked to Rotterdam CT classifications and GCS scores. Serum NOX2 levels effectively identified individuals at risk of death or poor prognosis at 180-day after sTBI. When compared to GCS scores and Rotterdam CT classifications, its predictive power was comparable. When the three variables were utilized together, the model's predictive ability was significantly higher than when they were independently used.

conclusionsNOX2 might be used as a potential biomarker to assess the severity of sTBI and foretell its outcome, since elevated serum NOX2 levels are significantly linked to increasing severity, 180-day mortality, and poor prognosis after sTBI.

Indexed as

Brain Injuries, TraumaticNADPH Oxidase 2AdultAgedBiomarkersFemaleGlasgow Coma ScaleGlasgow Outcome ScaleHumansMaleMiddle AgedPrognosisProspective StudiesBiomarkersCYBB protein, humanNADPH Oxidase 2mortalityNOX2poor prognosissevere traumatic brain injuryseverity

Identifiers

PMID40641341
PMCPMC12246553

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