ArticleBrain and behavior2025
Behavioral Settings are Crucial for Assessing Sensorimotor, Anxiety, and Social Changes in Aging and Spinal Cord Injury.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Experimental evidence of electroacupuncture in ALS mouse models: a systematic review and meta-analysis.Frontiers in neurologyPooled it
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Authors and funding
6 authors.
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Abstract
introductionFor decades, behavioral tests have been used to evaluate functions and dysfunctions of the central nervous system. The open field test is one of the most commonly used methods to assess murine behaviors, including exploration, spontaneous motor activity, and anxiety-like behaviors. The choice of open field shape can vary across studies, either to address specific research objectives or to simplify data acquisition and analysis.
methodsIn this study, we investigated whether the shape of the open field arena influences mice's behaviors in an age- and sex-dependent manner during physiological aging. We then assessed how the shape of the open field influences male mice's behaviors in an age-dependent manner following spinal cord injury.
resultsAcross physiological aging, we observed that the shape of the open field arena influenced motor activity, anxiety, and social behavior, with some gender differences. Following spinal cord injury, arena shape affected motor activity, tactile sensitivity, and social behavior in male mice, but anxiety-like behaviors remained unaffected.
conclusionOur results highlight that the shape of the arena significantly influences mouse behavior, emphasizing the importance of careful experimental protocol design in behavioral assessments.
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