Evidence map›Paper›PMID 40641311›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025

Kindlin-2 Deletion in Mural Cells Leads to Vascular Instability.

Katarzyna Bialkowska, Dorota Szpak, Dmitriy Verbovetskiy, Jun Qin, Olga A Cherepanova, Edward F Plow, Elzbieta Pluskota

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Kindlin-2 Deletion in Mural Cells Leads to Vascular Instability.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Katarzyna BialkowskaDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID https://orcid.org/0009-0000-4587-2089
Dorota SzpakDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0003-2761-5489
Dmitriy VerbovetskiyDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-3828-4200
Jun QinDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0002-2647-9270
Olga A CherepanovaDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0003-0045-8102
Edward F PlowDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0003-1531-9746
Elzbieta PluskotaDepartment of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0003-2924-3842

Funding

Project 3- Role of Leukocyte-Platelet Interactions in Inflammation and ThrombosisP01HL154811 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI SIMON, DANIEL I · 2021 to 2025
$12.1M
STRUCTURES AND MECHANISMS OF ANK REPEAT BEARING PROTEINSR01HL058758 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI JUN QIN · 1999 to 2026
$9.0M
Role of the TLR4 signaling in smooth muscle cell phenotypic transitionR01HL150193 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI CHEREPANOVA, OLGA · 2021 to 2024
$1.6M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 5P01 HL154811NHLBI NIH HHS P01 HL154811NHLBI NIH HHS R01 HL058758NHLBI NIH HHS R01 HL150193
6 · The paper itself

Abstract

Crucial to homeostasis, vascular barrier function depends upon coordinated interplay between endothelial (ECs) and mural cells, including vascular smooth muscle cells (vSMCs) and pericytes, that stabilize the vasculature. Kindlin-2 (K2) is an integrin co-activator regulating various cellular responses, but its role in mural cell-dependent vascular stabilization is unknown. The role of K2 in mural cell-mediated regulation of vascular barrier function was investigated. Vascular permeability was assessed in SMC/pericyte-specific tamoxifen-inducible K2 knockout (Fermt2

Indexed as

Capillary PermeabilityCytoskeletal ProteinsMuscle ProteinsMuscle, Smooth, VascularMyocytes, Smooth MusclePericytesAnimalsEndothelial CellsGene DeletionMaleMiceMice, Inbred C57BLMice, KnockoutCytoskeletal Proteinskindlin-2 protein, mouseMuscle ProteinshumanintegrinsKindlin‐2micepericytessepsisvascular permeabilityvascular smooth muscle

Identifiers

PMID40641311
PMCPMC12246818

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.