ArticleThe Laryngoscope2025
Mechanisms of Improving Feeding Function With Capsaicin Following Local Anesthesia in Infant Pigs.
Article in The Laryngoscope, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mechanisms of Improving Feeding Function With Capsaicin Following Local Anesthesia in Infant Pigs.The Laryngoscope · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
objectivesSensory deficits are detrimental to feeding performance, whereas sensory stimulation can improve feeding. Capsaicin is one sensory intervention that improves swallowing in adult humans and alters feeding in an infant animal model. This study assessed the role of the inferior alveolar nerve (IAN) in infant feeding, and determined whether capsaicin reversed or compensated for deficits associated with IAN anesthesia.
methodsData were collected using simultaneous videofluoroscopy and electromyography (EMG) in an infant pig model (n = 360 swallows, 6 pigs). Variables of interest included swallow frequency, sucks per swallow, milk acquired per suck, bolus size, degree of airway compromise, excursions of the tongue and thyroid cartilage, and activity of the digastric, genioglossus, and thyrohyoid. The repeated measures data were analyzed with a three- or four-level linear mixed model and (doubly) nested subsamples.
resultsIAN anesthetization decreased feeding efficiency as evidenced by decreased swallow frequency (p = 0.013), increased sucks per swallow (p = 0.016), decreased milk per suck (p = 0.008), and decreased bolus sizes (p = 0.036). Airway protection improved (p = 0.045) and tongue excursion was altered (p = 0.016), while digastric and genioglossus EMG were unchanged. Capsaicin application restored some, but not all variables, to baseline values, while either partially restoring or not affecting others.
conclusionsThe reduced efficiency following IAN anesthetization decreased instances of airway compromise, highlighting the tradeoff between feeding efficiency and airway protection. Subsequent capsaicin administration affected feeding physiology yet did not simply reverse deficits associated with impaired sensation. As such, capsaicin may be useful in treating some etiologies of dysphagia, but not others. LEVEL OF EVIDENCE: NA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.