Evidence map›Paper›PMID 40641262›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2025

Sonodynamic and Bioorthogonal Sonocatalytic Thrombotic Therapy Based on AIE Cationic Tetranuclear Ir(III) Complex Nanoplatform Guided by NIR-Chemiluminescence Imaging.

Zihan Wu, Liping Zhang, Ziwei Wang, Shengnan Liu, Qiaohua Zhang, Chunguang Shi, Yachao Wang, Gelin Xu, Dongxia Zhu, Martin R Bryce and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zihan WuKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province, 130024, China.
Liping ZhangDepartment of Neurology, Inst Translat Med, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035, China.
Ziwei WangKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province, 130024, China.
Shengnan LiuKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province, 130024, China.
Qiaohua ZhangKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province, 130024, China.
Chunguang ShiKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province, 130024, China.
Yachao WangDepartment of Neurology, Inst Translat Med, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035, China.
Gelin XuDepartment of Neurology, Inst Translat Med, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035, China.
Dongxia ZhuKey Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province, Department of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun, Jilin Province, 130024, China.
Martin R BryceDepartment of Chemistry, Durham University, Durham, UK.ORCID https://orcid.org/0000-0003-2097-7823
Lijie RenDepartment of Neurology, Inst Translat Med, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, 518035, China.
Ben Zhong TangSchool of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong (CUHK-Shenzhen), Shenzhen, Guangdong, 518172, China.

Funding

China Postdoctoral Science Foundation under 2021M692214Development and Reform Commission of Jilin Province 2024C017-4Engineering and Physical Sciences Research Council EP/L02621X/1National Natural Science Foundation of China 52473167National Natural Science Foundation of China M-0536National Science and Technology Major Project 2023ZD0504800National Science and Technology Major Project 2023ZD0504802Natural Science Foundation of Guangdong Province 2023A1515010169NSFC 52473167NSFC M-0536Science, Technology and Innovation Commission of Shenzhen Municipality ZDSYS20200811142600003Scientific and Technological Project of Jilin Province 20240402036GHShenzhen Clinical Research Center for Neurological Diseases LCYSSQ20220823091204009Shenzhen Science and Technology Program RCBS20210609104631086Team-based Medical Science Research Program 2024YZZ01
6 · The paper itself

Abstract

Non-invasive thrombolytic strategies include photothermal therapy (PTT), photodynamic therapy (PDT) and sonodynamic therapy (SDT). The development of PTT and PDT is impeded by the limited tissue penetration depth of the light source. SDT is a promising method due to the deeper tissue penetration and site-specific features of ultrasound; however, the scarcity of efficient sonosensitizers has constrained its clinical use. Herein, ultrasound-triggered nanoparticles (NPs), named Ir-4@S-R NPs, achieve a sonodynamic thrombolytic, bioorthogonal sonocatalytic reaction, with chemiluminescence (CL) imaging in the thrombus. An Ir(III) complex, named Ir-4, which has aggregation induced emission (AIE), combined with a hydrogen sulfide donor, named H

Indexed as

Coordination ComplexesIridiumNanoparticlesThrombolytic TherapyThrombosisUltrasonic TherapyAnimalsCatalysisHumansHydrogen SulfideInfrared RaysLuminescenceMiceRatsCoordination ComplexesHydrogen SulfideIridiumaggregation‐induced emissionbioorthogonal catalysisiridium complexnear‐infrared chemiluminescencesonodynamic therapy

Identifiers

PMID40641262
PMCPMC12506604

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.