Evidence map›Paper›PMID 40641160›Full record

ReviewPain management2025

Management of analgesia in cardiac surgery.

Alessandro Strumia, Mario Lusini, Fabio Costa, Elisabetta Stefani, Elena Cipollone, Livio Cusimano, Francesca Libri, Massimiliano Ricci, Alessandro Ruggiero, Domenico Sarubbi and 10 more

Abstract readReview
In one paragraph

Review in Pain management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Alessandro StrumiaOperative Research Unit of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.ORCID 0000-0002-3505-1153
Mario LusiniResearch Unit of Cardiac Surgery, Department of Cardiovascular Surgery, University Campus Bio-Medico di Roma, Roma, Italy.
Fabio CostaOperative Research Unit of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Elisabetta StefaniResearch Unit of Anaesthesia and Intensive Care, Department of Medicine, University Campus Bio-Medico di Roma, Roma, Italy.
Elena CipolloneResearch Unit of Anaesthesia and Intensive Care, Department of Medicine, University Campus Bio-Medico di Roma, Roma, Italy.
Livio CusimanoResearch Unit of Anaesthesia and Intensive Care, Department of Medicine, University Campus Bio-Medico di Roma, Roma, Italy.
Francesca LibriResearch Unit of Anaesthesia and Intensive Care, Department of Medicine, University Campus Bio-Medico di Roma, Roma, Italy.
Massimiliano RicciResearch Unit of Anaesthesia and Intensive Care, Department of Medicine, University Campus Bio-Medico di Roma, Roma, Italy.
Alessandro RuggieroResearch Unit of Anaesthesia and Intensive Care, Department of Medicine, University Campus Bio-Medico di Roma, Roma, Italy.
Domenico SarubbiOperative Research Unit of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Alessia MatteiOperative Research Unit of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Lorenzo SchiavoniOperative Research Unit of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Raffaele BarbatoOperative Research Unit of Cardiac Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Ciro MastroianniOperative Research Unit of Cardiac Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Mohamad JawabraResearch Unit of Cardiac Surgery, Department of Cardiovascular Surgery, University Campus Bio-Medico di Roma, Roma, Italy.
Felice Eugenio AgròOperative Research Unit of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Massimo ChelloResearch Unit of Cardiac Surgery, Department of Cardiovascular Surgery, University Campus Bio-Medico di Roma, Roma, Italy.
Rita CataldoOperative Research Unit of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Massimiliano CarassitiOperative Research Unit of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.
Giuseppe PascarellaOperative Research Unit of Anesthesia and Intensive Care, Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPain management in cardiac surgery remains a critical component of perioperative care, influencing recovery, patient satisfaction, and outcomes. Traditional opioid-based analgesia is associated with significant adverse effects, prompting the exploration of multimodal strategies, including regional anesthesia (RA), non-opioid analgesics, and enhanced recovery after surgery (ERAS) protocols.This review evaluates the evolution of cardiac surgery pain management, from conventional opioid-based regimens to multimodal approaches with regional anesthesia.

methodsA comprehensive analysis of existing literature was conducted, assessing the efficacy, safety, and integration of different pain management strategies in cardiac surgery on PubMed, Google Scholar, MEDLINE, UpToDate, Embase and Web of Science until 1 November 2024. Studies on opioids, adjunct analgesics (e.g. NSAIDs, acetaminophen, ketamine, dexmedetomidine), RA techniques, and ERAS frameworks were reviewed to provide a comparative perspective.

resultsMultimodal analgesia significantly reduces opioid consumption, enhances pain control, and minimizes complications such as respiratory depression and postoperative nausea. RA techniques, including fascial plane blocks, offer promising opioid-sparing benefits. ERAS protocols further optimize recovery, yet challenges remain in standardizing approaches across institutions.

conclusionsThe future of cardiac surgery pain management lies in individualized, multimodal strategies following ERAS principles. Standardized guidelines and further research are needed to refine these protocols for widespread adoption.

Indexed as

AnalgesiaCardiac Surgical ProceduresPain ManagementPostoperative PainAnalgesics, OpioidAnesthesia, ConductionHumansAnalgesics, OpioidanalgesiaCardiac surgeryERASperioperative managementregional anesthesia

Identifiers

PMID40641160
PMCPMC12707220

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.