Evidence map›Paper›PMID 40641158›Full record

SynthesisJournal of medical virology2025

Prevalence of HPV Infection Among Chinese Males With HPV-Related Diseases: A Systematic Review and Meta-Analysis.

Zexin Tao, Zhi Li, Baoli Chen, Xingxing Zhang, Rui Bian, Christine Velicer, Aiqiang Xu, Xiaodong Sun

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Journal of medical virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zexin TaoShandong Center for Disease Control and Prevention, Jinan, China.
Zhi LiInstitute of Immunization, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Baoli ChenValue & Implementation Global Medical & Scientific Affairs, MSD China, Shanghai, China.
Xingxing ZhangValue & Implementation Global Medical & Scientific Affairs, MSD China, Shanghai, China.
Rui BianValue & Implementation Global Medical & Scientific Affairs, MSD China, Shanghai, China.
Christine VelicerGlobal Medical and Scientific Affairs, Merck & Co. Inc., Rahway, New Jersey, USA.
Aiqiang XuShandong Center for Disease Control and Prevention, Jinan, China.
Xiaodong SunShanghai Municipal Center for Disease Control and Prevention, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence and impact of HPV infection among Chinese males have not been comprehensively explored. This systematic review and meta-analysis aims to investigate the prevalence of HPV infection among Chinese males diagnosed with HPV-related diseases. A systematic search was conducted across multiple electronic databases from inception to June 2023. Studies reporting the prevalence of HPV infection among Chinese males diagnosed with diseases potentially associated with HPV, without requiring sample type documentation, were included. Data extraction and quality assessment were performed independently by two reviewers. A random-effects meta-analysis was used to estimate the pooled prevalence of HPV infection. Among 105 studies on genital warts, the pooled prevalence was 81.25% for any HPV type, with 55.84% for low-risk (LR) genotypes and 20.11% for high-risk (HR) genotypes. Single infections (53.93%) were most common, with HPV 6 and 11 being the most prevalent. Among the LR genotypes, the prevalence was 73.76% for HPV 6 or 11. The most prevalent HR genotypes were HPV 16, 52, 58, 18, and 51. Among 102 studies on cancers, the prevalence was 10.83%, 28.97%, 28.14%, 19.50%, and 45.01% for oropharyngeal cancer, oral cancer, tonsil cancer, laryngeal cancer, and penile cancer, respectively. For anal cancer, one study reported 87.5% were HPV-positive. This study highlights the prevalence of HPV genotypes 6, 11, 16, 18, 52, and 58 in males with genital warts, and the prevalence of HPV 16 and 18 in males with cancers in which HPV has been detected. Future investment in resources focused on male is needed.

Indexed as

PapillomaviridaePapillomavirus InfectionsChinaCondylomata AcuminataEast Asian PeopleGenotypeHumansMalePrevalenceChinaHPVmaleprevalencesystematic review

Identifiers

PMID40641158
PMCPMC12269541

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.