ReviewPhysiological reports2025
Exercise and large airway issues.
Review in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exercise and large airway issues.Physiological reports · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The large airways, extending from the trachea to the main bronchi, respond dynamically to exercise-induced ventilatory demands. Large airway collapse (LAC) represents a spectrum of conditions characterized by excessive reduction in tracheal and/or main bronchial lumen during expiration. Utilizing the most common diagnostic criteria, defined as ≥50% reduction in airway cross-sectional area during expiration, LAC is a common finding in around one in three patients with underlying lung disease. However, it is also apparent that healthy, asymptomatic people meet this diagnostic criteria. Despite being recognized as a cause of exertional symptoms, the relationship between LAC and exercise-related symptoms or limitation is currently poorly understood. Traditional clinical approaches use forced expiratory measurements performed at rest during bronchoscopy or imaging studies to assess the condition. But novel tests, visualizing the large airways during exercise, may provide more physiologically relevant insight and are an important next step towards the development of targeted interventions for this clinical entity. This review aims to examine large airway behavior during different ventilatory challenges, with particular focus on comparing exercise hyperpnea with forced expiratory maneuvers.
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Registered trials
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