Evidence map›Paper›PMID 40640977›Full record

ReviewZoological research2025

Insight into molecular and neural mechanisms of general anesthesia from the invertebrate model

Jia-Yue Gao, Tao Luo, Chang Liu

Abstract readReview
In one paragraph

Review in Zoological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jia-Yue GaoSchool of Anesthesiology, Shandong Second Medical University, Weifang, Shandong 261053, China.
Tao LuoPeking University Shenzhen Hospital, Shenzhen, Guangdong 518036, China. E-mail: luotao_wh@yahoo.com.
Chang LiuFaculty of Life and Health Sciences, Shenzhen University of Advanced Technology, Shenzhen, Guangdong 518107, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

General anesthesia (GA) is a pharmacologically induced, reversible state characterized by unconsciousness, amnesia, analgesia, and immobility in response to noxious stimuli. Accumulating evidence from animal models has elucidated diverse mechanisms of the action underlying GA, including disruption of large-scale brain network connectivity, regulation of multiple neural pathways, and modulation of specific receptors and ion channels. Despite advances in dissecting the neurobiological basis of anesthetic action, the precise cellular and circuit-level processes remain incompletely understood, limiting the development of safer and more effective strategies. Recent studies in

Indexed as

Anesthesia, GeneralAnesthetics, GeneralDrosophila melanogasterAnimalsModels, AnimalAnesthetics, GeneralDrosophilaGeneral anesthesiaMolecular mechanismNeural circuitsSleepSynaptic release

Identifiers

PMID40640977
PMCPMC12464368

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.